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FLASH GENE
Symbol DPP4 contributors: mct - updated : 26-03-2014
HGNC name dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)
HGNC id 3009
Location 2q24.3      Physical location : 162.848.756 - 162.931.052
Synonym name
  • dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2)
  • T-cell activation antigen CD26
  • antigen CD26 (gp120), identified by monoclonal antibodies 134-2C2,TS145
  • Synonym symbol(s) CD26, ADCP2, ADABP, DPPIV, TP103
    EC.number 3.4.14.5
    DNA
    TYPE functioning gene
    STRUCTURE 82.00 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure functional HNF1 binding sites in the promoter region
    MAPPING cloned Y linked   status confirmed
    Physical map
    OR7E89P 2q31.3 olfactory receptor, family 7, subfamily E, member 89 pseudogene LOC391457 2 similar to putative taste receptor HTR2 OR7E90P 2q31.3 olfactory receptor, family 7, subfamily E, member 90 pseudogene MGC23908 2 similar to RNA polymerase B transcription factor 3 KIAA1728 2q24.2 KIAA1728 protein FLJ36175 2q24.2 hypothetical protein FLJ36175 BAZ2B 2q23-q24 bromodomain adjacent to zinc finger domain, 2B AXOT 2q24.2 axotrophin DCL-1 2q24.2 type I transmembrane C-type lectin receptor DCL-1 LY75 2p24 lymphocyte antigen 75 PLA2R1 2q23-q24.1 phospholipase A2 receptor 1, 180kDa ITGB6 2q24-q31 integrin, beta 6 RBMS1 2q24.2 RNA binding motif, single stranded interacting protein 1 TANK 2q24-q31 TRAF family member-associated NFKB activator PSMD14 2q24.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 TBR1 2q24 T-box, brain, 1 LOC285116 2q24.3 ELYS transcription factor-like protein TMBS62 pseudogene LOC391458 2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) SLC4A10 2q23-q24 solute carrier family 4, sodium bicarbonate transporter-like, member 10 DPP4 2q24.3 dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2) GCG 2q36-q37 glucagon FAP 2q23 fibroblast activation protein, alpha MDA5 2p24.3-q24.3 melanoma differentiation associated protein-5 GCA 2q24.3 grancalcin, EF-hand calcium binding protein KCNH7 2q24.3 potassium voltage-gated channel, subfamily H (eag-related), member 7 FIGN 2q24.2 fidgetin GRB14 2q22-q24 growth factor receptor-bound protein 14 KIAA0977 2q24.3 growth factor receptor-bound protein 14 FLJ39822 2q24.3 hypothetical protein FLJ39822
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   moderately
    Endocrineparathyroid   highly
    Reproductivefemale systemplacenta  highly
     male systemprostate  moderately
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidneytubuleconvoluted tubuleproximal tubulehighly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveepithelial cell
    Urinaryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Dpp4 (85.19 pc)
    homolog to murine Dpp4 (85.24 pc)
    intraspecies homolog to adenosine deaminase complexing protein-2
    Homologene
    FAMILY
  • peptidase S9B family
  • DPPIV subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    basic FUNCTION
  • serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides
  • nuclear DPP4 functions in the regulation of gene expression and tumor growth
  • DPP4 truncated-molecules have modified binding and functions compared with their full-length (FL) counterparts and may serve regulatory roles in normal and malignant hematopoiesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with ADA, in immunological synapse leading to a marked increase in the production of the T helper 1 and proimmflamatory cytokines IFN-gamma, TNF-alpha, and IL-6
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HNF1B
  • AGO1 directly interacts with POLR2A and is widely associated with chromosomal loci throughout the genome with preferential enrichment in promoters of transcriptionally active genes
  • nuclear DPP4 interacted with a genomic flanking region of the gene for POLR2A, a subunit of RNA polymerase II
  • PLG may regulate the DPP4 activity and the glucose metabolism
  • direct molecular link between TP53 and DPP4 in the control of lipid metabolism
  • DPP4/CD26 enzymatically cleaves select penultimate amino acids of proteins, including colony-stimulating factors (CSF2), and has been implicated in cellular regulation
  • cell & other
    REGULATION
    inhibited by GPC3 (Davoodi 2007)
    Other down regulated by hepatocyte nuclear factor 1 alpha & beta (HNF1A & HNF1B)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS