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FLASH GENE
Symbol DPP4 contributors: mct - updated : 26-03-2017
HGNC name dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)
HGNC id 3009
Location 2q24.3      Physical location : 162.848.756 - 162.931.052
Synonym name
  • dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2)
  • T-cell activation antigen CD26
  • antigen CD26 (gp120), identified by monoclonal antibodies 134-2C2,TS145
    • Synonym symbol(s) CD26, ADCP2, ADABP, DPPIV, TP103
    EC.number 3.4.14.5
    DNA
    TYPE functioning gene
    STRUCTURE 82.00 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure functional HNF1 binding sites in the promoter region
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   moderately
    Endocrineparathyroid   highly
    Reproductivefemale systemplacenta  highly
     male systemprostate  moderately
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidneytubuleconvoluted tubuleproximal tubulehighly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveepithelial cell
    Urinaryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Dpp4 (85.19 pc)
    homolog to murine Dpp4 (85.24 pc)
    intraspecies homolog to adenosine deaminase complexing protein-2
    Homologene
    FAMILY
  • peptidase S9B family
  • DPPIV subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    basic FUNCTION
  • serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides
  • nuclear DPP4 functions in the regulation of gene expression and tumor growth
  • DPP4 truncated-molecules have modified binding and functions compared with their full-length (FL) counterparts and may serve regulatory roles in normal and malignant hematopoiesis
  • functional role of DPP4 in SARS-CoV-2 infections
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with ADA, in immunological synapse leading to a marked increase in the production of the T helper 1 and proimmflamatory cytokines IFN-gamma, TNF-alpha, and IL-6
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HNF1B
  • AGO1 directly interacts with POLR2A and is widely associated with chromosomal loci throughout the genome with preferential enrichment in promoters of transcriptionally active genes
  • nuclear DPP4 interacted with a genomic flanking region of the gene for POLR2A, a subunit of RNA polymerase II
  • PLG may regulate the DPP4 activity and the glucose metabolism
  • direct molecular link between TP53 and DPP4 in the control of lipid metabolism
  • DPP4/CD26 enzymatically cleaves select penultimate amino acids of proteins, including colony-stimulating factors (CSF2), and has been implicated in cellular regulation
  • DPP4, AGTR2, SLC4A1, KREMEN1, ASGR1, ANP, TMEM30A, CLEC4G, and LDLRAD3, along with ACE2 facilitate SARS-CoV-2. virus entry and transmission
    • cell & other
    REGULATION
    inhibited by GPC3 (Davoodi 2007)
    Other down regulated by hepatocyte nuclear factor 1 alpha & beta (HNF1A & HNF1B)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    elevated DPP4 expression in naso- and oropharyngeal swabs of COVID-19 patient
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS