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FLASH GENE
Symbol DPP4 contributors: mct - updated : 26-03-2017
HGNC name dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)
HGNC id 3009
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Dpp4 (85.19 pc)
homolog to murine Dpp4 (85.24 pc)
intraspecies homolog to adenosine deaminase complexing protein-2
Homologene
FAMILY
  • peptidase S9B family
  • DPPIV subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    basic FUNCTION
  • serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides
  • nuclear DPP4 functions in the regulation of gene expression and tumor growth
  • DPP4 truncated-molecules have modified binding and functions compared with their full-length (FL) counterparts and may serve regulatory roles in normal and malignant hematopoiesis
  • functional role of DPP4 in SARS-CoV-2 infections
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with ADA, in immunological synapse leading to a marked increase in the production of the T helper 1 and proimmflamatory cytokines IFN-gamma, TNF-alpha, and IL-6
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HNF1B
  • AGO1 directly interacts with POLR2A and is widely associated with chromosomal loci throughout the genome with preferential enrichment in promoters of transcriptionally active genes
  • nuclear DPP4 interacted with a genomic flanking region of the gene for POLR2A, a subunit of RNA polymerase II
  • PLG may regulate the DPP4 activity and the glucose metabolism
  • direct molecular link between TP53 and DPP4 in the control of lipid metabolism
  • DPP4/CD26 enzymatically cleaves select penultimate amino acids of proteins, including colony-stimulating factors (CSF2), and has been implicated in cellular regulation
  • DPP4, AGTR2, SLC4A1, KREMEN1, ASGR1, ANP, TMEM30A, CLEC4G, and LDLRAD3, along with ACE2 facilitate SARS-CoV-2. virus entry and transmission
    • cell & other
    REGULATION
    inhibited by GPC3 (Davoodi 2007)
    Other down regulated by hepatocyte nuclear factor 1 alpha & beta (HNF1A & HNF1B)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    elevated DPP4 expression in naso- and oropharyngeal swabs of COVID-19 patient
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS