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FLASH GENE
Symbol DOCK8 contributors: mct - updated : 10-11-2007
HGNC name dedicator of cytokinesis 8
HGNC id 19191
Corresponding disease
DEL9P chromosome 9p distal deletion
Location 9p24.3      Physical location : 214.864 - 465.259
Synonym symbol(s) FLJ00026, FLJ00152, FLJ00346, ZIR8
DNA
TYPE functioning gene
STRUCTURE 192.00 kb     47 Exon(s)
motif
MAPPING cloned Y linked N status provisional
Physical map
NR1 9q34.3 NADPH-dependent FMN and FAD containing oxidoreductase LOC389822 9 similar to hypothetical protein FOXD4 9p24.3 forkhead box D4 LOC55871 9p24.3 COBW-like protein LOC392410 9 similar to NADPH-dependent FMN and FAD containing oxidoreductase NOXA1  NADPH oxidase activator 1 LOC389819 9 similar to cell recognition molecule CASPR3 isoform 1 LOC392412 9 similar to chromosome 9 open reading frame 7 UNQ2492 9 GLSR2492 LOC389820 9 similar to FK506-binding protein 4 (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (p59 protein) (HSP binding immunophilin) (HBI) (FKBP52 protein) (52 kDa FK506 binding protein) (FKBP59) SEMA4D 9q22-q31 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D LOC392406 9 similar to hypothetical protein LOC392411 9 similar to paranemin LOC389827 9 similar to RIKEN cDNA 1110002H13 C9orf66 9p24.3 chromosome 9 open reading frame 66 LOC392413 9 similar to MGC43306 protein LOC389701 9 similar to Dedicator of cytokinesis protein 6 DOCK8 9p24.3 dedicator of cytokinesis 8
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
47 - 7257 - 2031 - Ruusala (2004), Griggs (2008)
- - 4853 - 502 lung, kidney, spleen, thymus Griggs (2008)
- - 1938 - - in all fetal tissues Griggs(2008)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 spleen   highly
 thymus   highly
Nervousbrain   highly
Respiratorylung   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Respiratoryalveolar cell type 2
cell lineage
cell lines
fluid/secretion
at STAGE
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DHR-2(CZH-2) domain mediating some GEF activity
  • a DHR-1 (CZH-1) domain
  • a DOCK domain in the C-terminal region
  • HOMOLOGY
    interspecies homolog to DOCK1
    Homologene
    FAMILY DOCK family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in processes that affect the organisation of filamentous actin
  • play roles in regulation of migration, morphology, adhesion and growth of cells
  • possible involvement of DOCK8 in brain development and function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interact with CDC42, a small GTPase of the Rho subfamily
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL9P
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in primary lung cancers compared with normal lung tissue
    tumoral   deletion    
    in a gastric and a breast cancer cell line
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS