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FLASH GENE
Symbol DOCK8 contributors: mct - updated : 06-09-2017
HGNC name dedicator of cytokinesis 8
HGNC id 19191
Corresponding disease
DEL9P chromosome 9p distal deletion
HIES2 Hyper-IgE recurrent infection syndrome 2
Location 9p24.3      Physical location : 214.864 - 465.259
Synonym symbol(s) FLJ00026, FLJ00152, FLJ00346, ZIR8, HEL-205, MRD2
DNA
TYPE functioning gene
STRUCTURE 253.96 kb     47 Exon(s)
motif
MAPPING cloned Y linked N status provisional
Physical map
NR1 9q34.3 NADPH-dependent FMN and FAD containing oxidoreductase LOC389822 9 similar to hypothetical protein FOXD4 9p24.3 forkhead box D4 LOC55871 9p24.3 COBW-like protein LOC392410 9 similar to NADPH-dependent FMN and FAD containing oxidoreductase NOXA1  NADPH oxidase activator 1 LOC389819 9 similar to cell recognition molecule CASPR3 isoform 1 LOC392412 9 similar to chromosome 9 open reading frame 7 UNQ2492 9 GLSR2492 LOC389820 9 similar to FK506-binding protein 4 (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (p59 protein) (HSP binding immunophilin) (HBI) (FKBP52 protein) (52 kDa FK506 binding protein) (FKBP59) SEMA4D 9q22-q31 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D LOC392406 9 similar to hypothetical protein LOC392411 9 similar to paranemin LOC389827 9 similar to RIKEN cDNA 1110002H13 C9orf66 9p24.3 chromosome 9 open reading frame 66 LOC392413 9 similar to MGC43306 protein LOC389701 9 similar to Dedicator of cytokinesis protein 6 DOCK8 9p24.3 dedicator of cytokinesis 8
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
48 - 7470 - 2099 - 2008 18060736
46 - 7159 - 1999 lung, kidney, spleen, thymus 2008 18060736
47 - 7255 - 2031 in all fetal tissues 2008 18060736
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 spleen   highly
 thymus   highly
Nervousbrain   highly
Respiratorylung   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Respiratoryalveolar cell type 2
cell lineage
cell lines
fluid/secretion
at STAGE
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DHR-2(CZH-2) domain mediating some GEF activity
  • a DHR-1 (CZH-1) domain
  • a DOCK domain in the C-terminal region
  • HOMOLOGY
    interspecies homolog to DOCK1
    Homologene
    FAMILY DOCK family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • involved in processes that affect the organisation of filamentous actin
  • play roles in regulation of migration, morphology, adhesion and growth of cells
  • DOCK 8 was found to play an essential role in humoral immune responses and to be important in the proper formation of the B cell immunological synapse
  • is essential for T-cell survival and the maintenance of CD8+ T-cell memory
  • is a CDC42-specific guanine nucleotide exchange factor that is critical for interstitial Dendritic cells migration
  • important role for DOCK8 in NK cell effector function
  • is required for the development and survival of mature natural killer T (NKT) cells, suggesting that DOCK8 mediates survival signals within a specialized niche
  • possible involvement of DOCK8 in brain development and function
  • a critical role for DOCK8 in Treg cell homeostasis and function and the enforcement of peripheral B-cell tolerance
  • DOCK8-regulated shape integrity of lymphocytes prevents cytothripsis and promotes antiviral immunity in the skin
  • crucial role for DOCK8 in regulating the signal transduction events that control transcriptional activity, cytokine production and functional polarization of immune cells
  • regulates NK cell cytotoxicity and cytokine production in response to target cell engagement or receptor ligation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with CDC42, a small GTPase of the Rho subfamily
  • DOCK8 functions as an adaptor in a TLR9-MYD88 signaling pathway in B cells
  • DOCK8 interacts with STAT3 and regulates its activation and the outcome of STAT3-dependent TH17 differentiation
  • during macrophage migration, DOCK8 links CDC42 activation to actomyosin dynamics through the association with LURAP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL9P , HIES2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in primary lung cancers compared with normal lung tissue
    tumoral   deletion    
    in a gastric and a breast cancer cell line
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS