basic FUNCTION
| involved in processes that affect the organisation of filamentous actin |
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play roles in regulation of migration, morphology, adhesion and growth of cells |
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DOCK 8 was found to play an essential role in humoral immune responses and to be important in the proper formation of the B cell immunological synapse |
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is essential for T-cell survival and the maintenance of CD8+ T-cell memory |
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is a CDC42-specific guanine nucleotide exchange factor that is critical for interstitial Dendritic cells migration |
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important role for DOCK8 in NK cell effector function |
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is required for the development and survival of mature natural killer T (NKT) cells, suggesting that DOCK8 mediates survival signals within a specialized niche |
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possible involvement of DOCK8 in brain development and function |
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a critical role for DOCK8 in Treg cell homeostasis and function and the enforcement of peripheral B-cell tolerance |
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DOCK8-regulated shape integrity of lymphocytes prevents cytothripsis and promotes antiviral immunity in the skin |
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crucial role for DOCK8 in regulating the signal transduction events that control transcriptional activity, cytokine production and functional polarization of immune cells |
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regulates NK cell cytotoxicity and cytokine production in response to target cell engagement or receptor ligation |