| basic FUNCTION
| key regulatory protein during biogenic formation of mineral deposits |
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playing a regulatory role in dental mineralization |
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playing an important role in bone formation, and phosphate homeostasis |
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initiating osteoblast differentiation by transcription in the nucleus and orchestrating mineralized matrix formation extracellularly, at later stages of osteoblast maturation |
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may regulate FGF23 expression |
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involved directly or indirectly in controlling the production of the bone-derived hormone, FGF23 |
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distinct forms of DMP1 may work collectively in controlling the mineralization process  |
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acidic protein important to the formation of bone and dentin, primarily exists as the processed N-terminal and C-terminal fragments in the extracellular matrix of the two tissues |
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its proteolytic processing is an essential step in osteogenesis |
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required for phosphate homeostasis and mineralization |
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PHEX and DMP1 control a common pathway regulating bone mineralization and FGF23 production, the latter involving activation of the FGFR signaling in osteocytes |
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acidic protein that plays critical roles in osteogenesis and dentinogenesis |
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specifically involved in signaling via extracellular matrix-cell surface interaction |
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may be a physiological regulator of osteoblast/odontoblast-specific genes via the MAPK-ERK-JNK pathways |
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plays an essential role in tooth and bone mineralization and phosphate homeostasis |
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apart from its role as a constituent of dentin and bone matrix, DMP1 might play a regulatory role in the nucleus |
