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FLASH GENE
Symbol DMP1 contributors: mct/npt/pgu - updated : 20-06-2012
HGNC name dentin matrix acidic phosphoprotein
HGNC id 2932
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2645 - 497 - 2008 18819913
promote differential cell attachment and migration
6 - 2693 - 513 - 2008 18819913
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland     Homo sapiens
 tooth     Homo sapiens
Endocrinepancreas     Homo sapiens
Hearing/Equilibriumearinnercochlea  
Skeletonaxial skeleton   highly Homo sapiens
Urinarykidney     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveodontoblast Homo sapiens
Skeletonosteoblast Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid Hydrophobic
STRUCTURE
motifs/domains
  • multiple phosphorylation sites
  • disulfide-free flexible hydrophilic structures
  • presence of the integrin-binding tripeptide, arginine-glycine-aspartate (RGD)
  • aspartate-serine region homolog to the repeated motif ARSAM found on MEPE
  • isoforms Precursor inactive precursor and its proteolytic processing is an activation step essential to the biological functions of this protein in osteogenesis
    HOMOLOGY
    Homologene
    FAMILY
  • SIBLING (small integrin-binding ligand, N-linked glycoprotein) family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • primarily localized in the nuclear compartment of undifferentiated osteoblasts
  • localized in the nuclear compartment of preosteoblasts and preodontoblasts
  • nuclear DMP1 was restricted to the nucleoplasm but was absent in the nucleolus
  • basic FUNCTION
  • key regulatory protein during biogenic formation of mineral deposits
  • playing a regulatory role in dental mineralization
  • playing an important role in bone formation, and phosphate homeostasis
  • initiating osteoblast differentiation by transcription in the nucleus and orchestrating mineralized matrix formation extracellularly, at later stages of osteoblast maturation
  • may regulate FGF23 expression
  • involved directly or indirectly in controlling the production of the bone-derived hormone, FGF23
  • distinct forms of DMP1 may work collectively in controlling the mineralization process
  • acidic protein important to the formation of bone and dentin, primarily exists as the processed N-terminal and C-terminal fragments in the extracellular matrix of the two tissues
  • its proteolytic processing is an essential step in osteogenesis
  • required for phosphate homeostasis and mineralization
  • PHEX and DMP1 control a common pathway regulating bone mineralization and FGF23 production, the latter involving activation of the FGFR signaling in osteocytes
  • acidic protein that plays critical roles in osteogenesis and dentinogenesis
  • specifically involved in signaling via extracellular matrix-cell surface interaction
  • may be a physiological regulator of osteoblast/odontoblast-specific genes via the MAPK-ERK-JNK pathways
  • plays an essential role in tooth and bone mineralization and phosphate homeostasis
  • apart from its role as a constituent of dentin and bone matrix, DMP1 might play a regulatory role in the nucleus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RUNX2 in the developing skeleton
  • regulating DSPP ((association of DMP1 with the DSPP promoter, providing the foundation to understand how DMP1 regulates the expression of the DSPP gene)
  • binding of DMP1 to HSPA5 receptor (might be an important mechanism by which DMP1 is internalized and transported to the nucleus during bone and tooth development)
  • interacting with MMP2 (a peptide generated through the proteolytic processing of DMP1 by MMP2 can regulate the differentiation of mesenchymal cells during dentinogenesis and thus sustain reparative dentin formation in pathological situations such as carious decay)
  • inhibits VEGF-induced angiogenesis by blocking KDR phosphorylation
  • can bind to the the alpha V beta 3 integrin receptor, thereby transducing a signal to the intracellular aspect via PTK2 activation
  • DSPP is a downstream effector molecule that mediates the roles of DMP1 in dentinogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ARHP
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Dmp1 null mice display striking defects in bone structure