Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DLX1 contributors: mct/npt - updated : 25-01-2008
HGNC name distal-less homeo box 1
HGNC id 2914
Corresponding disease
DEL2Q31 chromosome 2q interstitial deletion, including 2q31.1
Location 2q31.1      Physical location : 172.950.207 - 172.954.399
DNA
TYPE functioning gene
STRUCTURE 4.19 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2403 27.2 255 - Liu (2009)
2 - 2203 13.4 129 - Liu (2009)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text forebrain, facial and limb primordia
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix, DNA binding domain
  • HOMOLOGY
    interspecies homolog to Drosophila distal less Dlx1
    Homologene
    FAMILY
  • distal-less homeobox family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • likely playing a regulatory role in the development of the ventral forebrain
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by MSX1 (strongly up-regulated the Delta-Notch pathway genes DLK1, NOTCH3, and HEY1) (Revet 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2Q31
    Susceptibility to autism autism spectrum disorders
    Variant & Polymorphism SNP increasing the risk of autism spectrum disorders (Liu 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS