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FLASH GENE
Symbol DLX1 contributors: mct/npt - updated : 25-01-2008
HGNC name distal-less homeo box 1
HGNC id 2914
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix, DNA binding domain
  • HOMOLOGY
    interspecies homolog to Drosophila distal less Dlx1
    Homologene
    FAMILY
  • distal-less homeobox family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • likely playing a regulatory role in the development of the ventral forebrain
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by MSX1 (strongly up-regulated the Delta-Notch pathway genes DLK1, NOTCH3, and HEY1) (Revet 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2Q31
    Susceptibility to autism autism spectrum disorders
    Variant & Polymorphism SNP increasing the risk of autism spectrum disorders (Liu 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS