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FLASH GENE
Symbol DGKE contributors: mct/npt - updated : 10-11-2014
HGNC name diacylglycerol kinase, epsilon 64kDa
HGNC id 2852
Corresponding disease
NPHS7 nephrotic syndrome, type 7
Location 17q22      Physical location : 54.911.459 - 54.946.034
Synonym name DAG kinase epsilon
Synonym symbol(s) DAGK6, DGK, DAGK5, DAGK6-PEN
EC.number 2.7.1.107
DNA
TYPE functioning gene
STRUCTURE 34.58 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 7784 63 567 - 2007 17455907
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
Reproductivefemale systemuteruscervix highly
 female systembreastmammary gland highly
 male systemtestis  predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal phorbol esters/diacylglycerol binding domain (C1 domain) with finger-like structures but lacking the EF hand motif
  • a diacylglycerol (DAG) catalytic domain with two ATP-binding motifs
  • a DAG accessory domain
  • a region responsible for the arachidonoyl specificity is the lipoxygenase (LOX)-like motif (LOXL) found in the accessory domain, adjacent to DGKE catalytic site
  • a segment of hydrophobic amino acids, not contributing to substrate specificity but playing a role in permanently sequestering the enzyme to a membrane
  • HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic diacetylglycerol kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • converting diacylglycerol to phosphatidic acid
  • involved in the phosphorylation of arachidonate containing diacylglycerol
  • may be be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction
  • plays an important role in the resynthesis of phosphatidylinositol by mediating the phosphorylation of diacylglycerol to phosphatidic acid
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacts with actin stress fibers and is involved in their stability in vascular smooth muscle cells
  • cell & other
    REGULATION
    Other dual acyl chain selectivity is used to negatively regulate its enzymatic activity in a manner that ensures DGKE remains committed to the PI turnover cycle
    ASSOCIATED DISORDERS
    corresponding disease(s) NPHS7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS