motifs/domains
| N terminal phorbol esters/diacylglycerol binding domain (C1 domain) with finger-like structures but lacking the EF hand motif, and a zinc finger motif of the C1B domain is critical for stability and activity of DGKE |
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a diacylglycerol (DAG) catalytic domain with two ATP-binding motifs |
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a DAG accessory domain |
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a region responsible for the arachidonoyl specificity is the lipoxygenase (LOX)-like motif (LOXL) found in the accessory domain, adjacent to DGKE catalytic site |
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a segment of hydrophobic amino acids, not contributing to substrate specificity but playing a role in permanently sequestering the enzyme to a membrane |