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FLASH GENE
Symbol DGKE contributors: mct/npt - updated : 06-12-2023
HGNC name diacylglycerol kinase, epsilon 64kDa
HGNC id 2852
DNA
TYPE functioning gene
STRUCTURE 34.58 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 7784 63 567 - 2007 17455907
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
Reproductivefemale systemuteruscervix highly
 female systembreastmammary gland highly
 male systemtestis  predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal phorbol esters/diacylglycerol binding domain (C1 domain) with finger-like structures but lacking the EF hand motif, and a zinc finger motif of the C1B domain is critical for stability and activity of DGKE
  • a diacylglycerol (DAG) catalytic domain with two ATP-binding motifs
  • a DAG accessory domain
  • a region responsible for the arachidonoyl specificity is the lipoxygenase (LOX)-like motif (LOXL) found in the accessory domain, adjacent to DGKE catalytic site
  • a segment of hydrophobic amino acids, not contributing to substrate specificity but playing a role in permanently sequestering the enzyme to a membrane
  • HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic diacetylglycerol kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • converting diacylglycerol to phosphatidic acid
  • involved in the phosphorylation of arachidonate containing diacylglycerol
  • may be be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction
  • plays an important role in the resynthesis of phosphatidylinositol by mediating the phosphorylation of diacylglycerol to phosphatidic acid
  • role of DGKE in the induction of cyclooxygenase-2 and in the regulation of glomerular prostanoids synthesis under stress
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacts with actin stress fibers and is involved in their stability in vascular smooth muscle cells
  • DGKE regulated Klotho expression, at least partly via the transcription factor Krüppel-like factor (KLF15)
  • cell & other
    REGULATION
    Other dual acyl chain selectivity is used to negatively regulate its enzymatic activity in a manner that ensures DGKE remains committed to the PI turnover cycle
    ASSOCIATED DISORDERS
    corresponding disease(s) NPHS7
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    causes thrombotic microangiopathy by impairing endothelial VEGFA signaling
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneousurinary 
    DGKE may present an innovative therapeutic strategy for treating patients with acute kidney injury (AKI)
    ANIMAL & CELL MODELS
  • Dgke null mice present subclinical microscopic anomalies of the glomerular endothelium and basal membrane that worsen with age and develop glomerular capillary occlusion when exposed to nephrotoxic serum