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FLASH GENE
Symbol DGAT1 contributors: mct - updated : 11-10-2018
HGNC name diacylglycerol O-acyltransferase homolog 1 (mouse)
HGNC id 2843
Corresponding disease
DIAR7 Diarrhea 7
Location 8q24.3      Physical location : 145.538.246 - 145.550.567
Synonym name
  • acyl CoA : cholesterol acyltransferase related gene product 1
  • diglyceride acyltransferase
  • acyl coenzyme A:cholesterol acyltransferase related gene 1
  • Synonym symbol(s) AGRT1, DGAT, ARGP1, ARAT, DIAR7
    EC.number 2.3.1.20/2.3.1.76
    DNA
    TYPE functioning gene
    STRUCTURE 12.32 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    motif repetitive sequence   ALU
    MAPPING cloned Y linked N status provisional
    Physical map
    CYC1 8q24.3 cytochrome c-1 DKFZP434N1923 8q24.3 hypothetical protein DKFZp434N1923 MAF1 8q24.3 homolog of yeast MAF1 KIAA1875 8q24.3 hypothetical protein KIAA1875 LOC51236 8q24.3 brain protein 16 LOC392276 8 similar to RIKEN cDNA 1700091F14 LOC392277 8 similar to RIKEN cDNA 1700091F14 KIAA1833 8q24.3 hypothetical protein KIAA1833 BOP1 8q24.3 block of proliferation 1 HSF1 8q24.3 heat shock transcription factor 1 DGAT1 8q24.3 diacylglycerol O-acyltransferase homolog 1 (mouse) DKFZp547F072 8q24.3 hypothetical protein DKFZp547F072 SCRT1 8q24.3 scratch homolog 1, zinc finger protein (Drosophila) LOC340393 8q24.3 similar to unnmaed protein product FBXL6 8q24-q25 F-box and leucine-rich repeat protein 6 FLJ11856 8q24.3 putative G-protein coupled receptor GPCR41 ADCK5 8q24.3 aarF domain containing kinase 5 CPSF1 8q24-q23 cleavage and polyadenylation specific factor 1, 160kDa SLC39A4 8q24.3 solute carrier family 39 (zinc transporter), member 4 VPS28 8q24.3 vacuolar protein sorting 28 (yeast) NFKBIL2 8q24.3 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 MGC13010 8q24.3 hypothetical protein MGC13010 KIFC2 8q24.3 likely ortholog of mouse kinesin family member C2 FOXH1 8q24.3 forkhead box H1 PPP1R16A 8q24.3 protein phosphatase 1, regulatory (inhibitor) subunit 16A GPT 8q24.3 glutamic-pyruvate transaminase (alanine aminotransferase) LOC113655 8q24.3 hypothetical protein BC011982 RECQL4 8q24.3 RecQ protein-like 4 KIAA0014 8q24.3 RecQ protein-like 4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 3718 55 488 - 1998 9756920
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine    Homo sapiens
    Reproductivemale systemprostate   
    Visualeyeretina    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningretinal pigment epithelium (RPE)   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    VisualMuller cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to murine Dgat1
    Homologene
    FAMILY
  • sterol-o-acyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,microsome
    text
  • reside in the endoplasmic reticulum (ER)
  • transmembrane proteins localized in the endoplasmic reticulum
  • basic FUNCTION
  • catalyzing the terminal step in triacylglycerol synthesis involved in fat absorption, lipoprotein assembly, adipose tissue formation and lactation
  • may play an active role in metabolic "remodeling" of skeletal muscle coupled with insulin sensitization
  • its induction could be beneficial in the setting of excess heart accumulation of toxic lipids
  • important protein that participates in the effect of HNF4A on hepatic secretion of triglyceride-rich lipoproteins
  • DGAT1 and DGAT2 account for nearly all triacylglycerol synthesis in adipocytes and appear to be required for lipid droplet formation during adipogenesis
  • plays a significant role in dietary triacylglycerol (TAG) absorption in the small intestine
  • belongs to the family of oligomeric membrane proteins that adopt a dual membrane topology
  • catalyze the final step in triglyceride synthesis
  • DGAT1 and DGAT2 can compensate for each other to synthesize triacylglycerol, but triacylglycerol synthesized by DGAT1 is preferentially channeled to oxidation, whereas DGAT2 synthesizes triacylglycerol destined for very low-density lipoprotein assembly
  • DGAT1 catalyzes the synthesis of retinyl esters in retina from multiple retinol isomers with similar catalytic efficiencies
  • key enzyme in triglyceride (TG) biogenesis, is highly associated with metabolic abnormalities, such as obesity and type 2 diabetes
  • DGAT1 and DGAT2 function coordinately to regulate the process of dietary fat absorption by preferentially synthesizing triacylglycerol(TAG) for incorporation into distinct subcellular TAG pools in enterocytes
  • important role for DGAT activity and TG synthesis generally in averting ER stress and lipotoxicity, with specifically DGAT1 performing this function during stimulated lipolysis in adipocytes
  • DGAT1 is involved in the synthesis of triacylglycerol where as ABHD5 is a hydrolase and participates in the fatty acid oxidation process, yet inhibition of both enzymes similarly promotes prostate cancer cell death
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other DGAT1 inhibition perturbs postprandial gut hormone release
    ASSOCIATED DISORDERS
    corresponding disease(s) DIAR7
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    failing human hearts have severely reduced DGAT1 expression associated with accumulation of DAGs and ceramides
    Susceptibility coronary heart disease
    Variant & Polymorphism
    Candidate gene C79T polymorphism with decreased risk of coronary heart disease
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetemetabolic syndrom 
    pharmacological inhibition of DGAT1 holds promise in treating diverse metabolic disorders
    metabolismlipidcholesterol
    targeting intestinal DGAT1 may represent a novel approach for treating hypercholesterolemia
    ANIMAL & CELL MODELS
  • overexpressed in murine,white adipose tissue increases body fat (obesity) but not glucose disposal
  • Dgat1(-/-) mice exhibit a number of beneficial metabolic effects including reduced obesity and improved insulin sensitivity and no known cardiac dysfunction