SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,matrix
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,cytosolic,microsome
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text
| reside in the endoplasmic reticulum (ER) |
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transmembrane proteins localized in the endoplasmic reticulum |
basic FUNCTION
| catalyzing the terminal step in triacylglycerol synthesis involved in fat absorption, lipoprotein assembly, adipose tissue formation and lactation |
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may play an active role in metabolic "remodeling" of skeletal muscle coupled with insulin sensitization |
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its induction could be beneficial in the setting of excess heart accumulation of toxic lipids |
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important protein that participates in the effect of HNF4A on hepatic secretion of triglyceride-rich lipoproteins |
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DGAT1 and DGAT2 account for nearly all triacylglycerol synthesis in adipocytes and appear to be required for lipid droplet formation during adipogenesis |
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plays a significant role in dietary triacylglycerol (TAG) absorption in the small intestine |
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belongs to the family of oligomeric membrane proteins that adopt a dual membrane topology |
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catalyze the final step in triglyceride synthesis |
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DGAT1 and DGAT2 can compensate for each other to synthesize triacylglycerol, but triacylglycerol synthesized by DGAT1 is preferentially channeled to oxidation, whereas DGAT2 synthesizes triacylglycerol destined for very low-density lipoprotein assembly |
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DGAT1 catalyzes the synthesis of retinyl esters in retina from multiple retinol isomers with similar catalytic efficiencies |
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key enzyme in triglyceride (TG) biogenesis, is highly associated with metabolic abnormalities, such as obesity and type 2 diabetes |
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DGAT1 and DGAT2 function coordinately to regulate the process of dietary fat absorption by preferentially synthesizing triacylglycerol(TAG) for incorporation into distinct subcellular TAG pools in enterocytes |
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important role for DGAT activity and TG synthesis generally in averting ER stress and lipotoxicity, with specifically DGAT1 performing this function during stimulated lipolysis in adipocytes |
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DGAT1 is involved in the synthesis of triacylglycerol where as ABHD5 is a hydrolase and participates in the fatty acid oxidation process, yet inhibition of both enzymes similarly promotes prostate cancer cell death |