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FLASH GENE
Symbol DDX41 contributors: mct - updated : 01-12-2014
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
HGNC id 18674
Location 5q35.3      Physical location : 176.938.578 - 176.943.967
Synonym name
  • probable ATP-dependent RNA helicase DDX41
  • DEAD box protein 41
  • DEAD-box protein abstrakt
  • putative RNA helicase
  • Synonym symbol(s) ABS, MGC8828
    EC.number 3.6.4.13
    DNA
    TYPE functioning gene
    STRUCTURE 5.39 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389348 5 LOC389348 KIAA1976 5q35.3 netrin receptor Unc5h1 HK3 5q35.2-q35.3 hexokinase 3 (white cell) RAP80 5q35.3 receptor associated protein 80 JAZ 5q35.3 double-stranded RNA-binding zinc finger protein JAZ FGFR4 5q35.3 fibroblast growth factor receptor 4 NSD1 5q35.1-q35.3 nuclear receptor binding SET domain protein 1 RAB24 5q35.3 RAB24, member RAS oncogene family PX19 5q35.3 px19-like protein MXD3 5q35.3 MAX dimerization protein 3 LMAN2 5q35 lectin, mannose-binding 2 RGS14 5q35.3 regulator of G-protein signalling 14 SLC34A1 5q35.1 solute carrier family 34 (sodium phosphate), member 1 LOC345456 5q35.3 similar to profilin 3 F12 5q35.1 coagulation factor XII (Hageman factor) GPRK6 5q35 G protein-coupled receptor kinase 6 MGC10772 5q35.3 hypothetical protein MGC10772 DBN1 5q35.3 drebrin 1 FLJ22570 5q35.3 Dok-like protein DDX41 5q35.3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 HSGP25L2G 5q35.3 gp25L2 protein LOC391854 5 similar to Beta-1,4-galactosyltransferase 7 (Beta-1,4-GalTase 7) (Beta4Gal-T7) (b4Gal-T7) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7) ENIGMA 5q34-q35 similar to Beta-1,4-galactosyltransferase 7 (Beta-1,4-GalTase 7) (Beta4Gal-T7) (b4Gal-T7) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7) FLJ10404 5q35.3 hypothetical protein FLJ10404 B4GALT7 5q35.2-q35.3 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) LOC202181 5q35.3 hypothetical protein LOC202181 NY-REN-7 5q35.3 NY-REN-7 antigen LOC391855 5 similar to olfactory receptor MOR126-1 LOC389349 5 hypothetical gene supported by NM_032361 LOC285647 5q35.3 similar to FLJ00052 protein PROP1 5q11.2 prophet of Pit1, paired-like homeodomain transcription factor LOC389350 5 similar to KIAA0752 protein LOC285658 5q35.3 similar to 60S ribosomal protein L19 N4BP3 5q35.3 similar to 60S ribosomal protein L19 FLJ22318 5q35.3 hypothetical protein FLJ22318 NOLA2 5q35 nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 2118 - 622 - 2003 12782131
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
     stomach   highly
    Lymphoid/Immunethymus   highly
    Nervousbrain   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain interacting with the phox homology (PX) domain of SNX2
  • one CCHC type zinc finger domain
  • one helicase ATP-binding domain
  • one helicase C-terminal domain
  • HOMOLOGY
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX41 subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    basic FUNCTION
  • playing a role during morphogenetic process, apoptosis and the establishment of cell polarity especially in visual system development
  • may function in dendritic cells as a DNA sensor to activate TMEM173-dependent innate immune responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pattern-recognition receptor (PRR) that sensed both c-di-GMP and c-di-AMP
  • protein SNX2-interacting protein (regulates the expression of sorting nexin-2)
  • DDX41 is an additional DNA sensor that depends on TMEM173 to sense pathogenic DNA
  • forms a complex with TMEM173 to signal to TBK1-IRF3 and activate the interferon response
  • TRIM21 is a DDX41-interacting protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS