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FLASH GENE
Symbol DDX41 contributors: mct - updated : 01-12-2014
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
HGNC id 18674
Location 5q35.3      Physical location : 176.938.578 - 176.943.967
Synonym name
  • probable ATP-dependent RNA helicase DDX41
  • DEAD box protein 41
  • DEAD-box protein abstrakt
  • putative RNA helicase
    • Synonym symbol(s) ABS, MGC8828
    EC.number 3.6.4.13
    DNA
    TYPE functioning gene
    STRUCTURE 5.39 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 2118 - 622 - 2003 12782131
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
     stomach   highly
    Lymphoid/Immunethymus   highly
    Nervousbrain   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain interacting with the phox homology (PX) domain of SNX2
  • one CCHC type zinc finger domain
  • one helicase ATP-binding domain
  • one helicase C-terminal domain
    • HOMOLOGY
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX41 subfamily
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    basic FUNCTION
  • playing a role during morphogenetic process, apoptosis and the establishment of cell polarity especially in visual system development
  • may function in dendritic cells as a DNA sensor to activate TMEM173-dependent innate immune responses
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pattern-recognition receptor (PRR) that sensed both c-di-GMP and c-di-AMP
    • protein SNX2-interacting protein (regulates the expression of sorting nexin-2)
  • DDX41 is an additional DNA sensor that depends on TMEM173 to sense pathogenic DNA
  • forms a complex with TMEM173 to signal to TBK1-IRF3 and activate the interferon response
  • TRIM21 is a DDX41-interacting protein
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS