Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DDX41 contributors: mct - updated : 01-12-2014
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
HGNC id 18674
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
 stomach   highly
Lymphoid/Immunethymus   highly
Nervousbrain   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain interacting with the phox homology (PX) domain of SNX2
  • one CCHC type zinc finger domain
  • one helicase ATP-binding domain
  • one helicase C-terminal domain
  • HOMOLOGY
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX41 subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    basic FUNCTION
  • playing a role during morphogenetic process, apoptosis and the establishment of cell polarity especially in visual system development
  • may function in dendritic cells as a DNA sensor to activate TMEM173-dependent innate immune responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pattern-recognition receptor (PRR) that sensed both c-di-GMP and c-di-AMP
  • protein SNX2-interacting protein (regulates the expression of sorting nexin-2)
  • DDX41 is an additional DNA sensor that depends on TMEM173 to sense pathogenic DNA
  • forms a complex with TMEM173 to signal to TBK1-IRF3 and activate the interferon response
  • TRIM21 is a DDX41-interacting protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS