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FLASH GENE
Symbol CYP2C19 contributors: mct - updated : 18-04-2019
HGNC name cytochrome P450, family 2, subfamily C, polypeptide 19
HGNC id 2621
Corresponding disease
CYP2C19DM drug metabolism, CYP2C19-related
Location 10q23.33      Physical location : 96.522.462 - 96.612.670
Genatlas name xenobiotic monooxygenase
Synonym name
  • S-mephenytoin 4-hydroxylase
  • flavoprotein-linked monooxygenase
  • microsomal monooxygenase
  • Synonym symbol(s) CPC1, CYP2C, P450C2C, CPCJ
    EC.number 1.14.14.51
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 92.87 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned N linked N status confirmed
    Map cen - CYP2C18 - CYP2C19 - CYP2C9 - CYP2C8 - qter
    Authors Gray (95), Finta (00)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 4135 - 490 - 2004 15128046
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to C.Elegans C12D6.7
    Homologene
    FAMILY
  • cytochrome P450 subfamily IIC
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • involved in hydroxylation of mephenytoin and other xenobiotics (omeprazole)
  • cytochrome P450 monooxygenase that contributes significantly to metabolic clearance of several widely prescribed drugs
  • CYP2C19 genotypes had significant impact on clopidogrel response and prognosis of patients with stroke
  • plays a role in the biotransformation of clinically relevant drugs as well as endogenous compounds, including sex hormones, which are known to be modulators of food intake and energy balance
  • is an important member of the cytochrome P450 (CYP450) enzyme super family and is responsible for clearing approximately 10p 100 of commonly used clinical drugs that undergo phase I metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    PATHWAY
    metabolism drug
    signaling
    oxidative metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH, heme
    protein
  • flavoprotein P450 oxidoreductase (POR)
  • 'master regulator' of CYP2C19 transcription could likely itself be a target of epigenetic control
  • cell & other
    REGULATION
    induced by drugs,pesticides carcinogens
    ASSOCIATED DISORDERS
    corresponding disease(s) CYP2C19DM
    related resource Human Cytochrome P450 (CYP) Allele Nomenclature Committee
    Susceptibility
  • to poor metabolizer phenotype
  • to essential tremor
  • to valproic acid-induced weight gain in epileptic females
  • to recurrence of cerebral ischemic stroke
  • to hypertension
  • Variant & Polymorphism SNP
  • increasing the risk of essential tremor
  • CYP2C19*17 allele corresponding to the extensive metabolizer phenotype was associated with anti-reflux surgery (ARS), following failed proton pump inhibitor medication treatment
  • two CYP2C19 variants (CYP2C19*3 and *35FS) had no detectable enzyme activity on methadone metabolism
  • relationship between the CYP2C19 polymorphism and VPA-induced weight gain in female patients with epilepsy
  • AA genotype and A allele of CYP2C19 G681A may be related to the occurrence and recurrence of cerebral ischemic stroke
  • AA genotype of rs10509676 was found more frequently in the hypertension group than in the control group
  • Candidate gene
    Marker
  • CYP2C19 polymorphism is associated with endometrisis and can be considered a potential biomarker of the disease
  • Therapy target
    ANIMAL & CELL MODELS