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FLASH GENE
Symbol CYP2C19 contributors: mct - updated : 18-04-2019
HGNC name cytochrome P450, family 2, subfamily C, polypeptide 19
HGNC id 2621
Corresponding disease
CYP2C19DM drug metabolism, CYP2C19-related
Location 10q23.33      Physical location : 96.522.462 - 96.612.670
Genatlas name xenobiotic monooxygenase
Synonym name
  • S-mephenytoin 4-hydroxylase
  • flavoprotein-linked monooxygenase
  • microsomal monooxygenase
  • Synonym symbol(s) CPC1, CYP2C, P450C2C, CPCJ
    EC.number 1.14.14.51
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 92.87 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned N linked N status confirmed
    Map cen - CYP2C18 - CYP2C19 - CYP2C9 - CYP2C8 - qter
    Authors Gray (95), Finta (00)
    Physical map
    KIF11 10q24.1 kinesin family member 11 LOC283014 10q23.33 similar to eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa; eukaryotic translation initiation factor 2, subunit 2 (beta, 38kD ); eukaryotic initiation factor 2-beta HHEX 10q24 hematopoietically expressed homeobox SEC15L1 10q23.33 SEC15-like 1 (S. cerevisiae) CYP26C1 10q23.33 cytochrome P450, family 26, subfamily C, polypeptide 1 CYP26A1 10q23-q24 cytochrome P450, family 26, subfamily A, polypeptide 1 LOC389997 10 similar to Saccharomyces cerevisiae Nip7p homolog LOC387703 10 similar to ATP-dependent DNA helicase II, 70 kDa subunit (Lupus Ku autoantigen protein p70) (Ku70) (70 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box binding factor 75 kDa subunit) (CTCBF) (CTC75) LOC389998 10 similar to 60S ribosomal protein L17 (L23) FER1L3 10q23.3 fer-1-like 3, myoferlin (C. elegans) C10orf3 10q23.33 chromosome 10 open reading frame 3 GPR120 10q23.33 G protein-coupled receptor 120 RBP4 10q24 retinol binding protein 4, plasma PDE6C 10q24 phosphodiesterase 6C, cGMP-specific, cone, alpha prime C10orf4 10q23.33 chromosome 10 open reading frame 4 LGI1 10q24 leucine-rich, glioma inactivated 1 FLJ33990 10q23.33 hypothetical protein FLJ33990 PSMD4P2 10q23.33 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4, pseudogene 2 PLCE1 10q23 phospholipase C, epsilon 1 AD24 10q23.33 AD24 protein KIAA0608 10q23.33 KIAA0608 protein HELLS 10q23-q24 helicase, lymphoid-specific CYP2C18 10q24 cytochrome P450, family 2, subfamily C, polypeptide 18 CYP2C19 10q24 cytochrome P450, family 2, subfamily C, polypeptide 19 CYP2C9 10q24.1 cytochrome P450, family 2, subfamily C, polypeptide 9 CYP2C8 10q23.33 cytochrome P450, family 2, subfamily C, polypeptide 8 LOC387705 10 LOC387705 LOC142827 10q24.1 similar to Hypothetical protein MGC56918 PDLIM1 10q22-q26.3 PDZ and LIM domain 1 (elfin) SORBS1 10q23.3-q24.1 sorbin and SH3 domain containing 1 LOC389999 10 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 PYCS 10q24.3 pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase) DKFZP564D116 10q24.1 DKFZP564D116 protein ENTPD1 10q24 ectonucleoside triphosphate diphosphohydrolase 1 LOC387706 10 LOC387706 LOC387707 10 similar to RIKEN cDNA 5730509K17 gene FLJ10895 10pter-q26.12 hypothetical protein FLJ10895 KIAA0335 10cen-q26.11 hypothetical protein FLJ10895 LOC387708 10 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 BLNK 10q23.2 B-cell linker DNTT 10q24 deoxynucleotidyltransferase, terminal TMEM10 10q23-q24 transmembrane protein 10 TLL2 10q23-q24 tolloid-like 2 SMBP 10q24.2 SM-11044 binding protein PIK3AP1 10q24.2 phosphoinositide-3-kinase adaptor protein 1 LOC283340 10q24.2 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein LOC387709 10 LOC387709
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 4135 - 490 - 2004 15128046
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to C.Elegans C12D6.7
    Homologene
    FAMILY
  • cytochrome P450 subfamily IIC
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • involved in hydroxylation of mephenytoin and other xenobiotics (omeprazole)
  • cytochrome P450 monooxygenase that contributes significantly to metabolic clearance of several widely prescribed drugs
  • CYP2C19 genotypes had significant impact on clopidogrel response and prognosis of patients with stroke
  • plays a role in the biotransformation of clinically relevant drugs as well as endogenous compounds, including sex hormones, which are known to be modulators of food intake and energy balance
  • is an important member of the cytochrome P450 (CYP450) enzyme super family and is responsible for clearing approximately 10p 100 of commonly used clinical drugs that undergo phase I metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    PATHWAY
    metabolism drug
    signaling
    oxidative metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH, heme
    protein
  • flavoprotein P450 oxidoreductase (POR)
  • 'master regulator' of CYP2C19 transcription could likely itself be a target of epigenetic control
  • cell & other
    REGULATION
    induced by drugs,pesticides carcinogens
    ASSOCIATED DISORDERS
    corresponding disease(s) CYP2C19DM
    related resource Human Cytochrome P450 (CYP) Allele Nomenclature Committee
    Susceptibility
  • to poor metabolizer phenotype
  • to essential tremor
  • to valproic acid-induced weight gain in epileptic females
  • to recurrence of cerebral ischemic stroke
  • to hypertension
  • Variant & Polymorphism SNP
  • increasing the risk of essential tremor
  • CYP2C19*17 allele corresponding to the extensive metabolizer phenotype was associated with anti-reflux surgery (ARS), following failed proton pump inhibitor medication treatment
  • two CYP2C19 variants (CYP2C19*3 and *35FS) had no detectable enzyme activity on methadone metabolism
  • relationship between the CYP2C19 polymorphism and VPA-induced weight gain in female patients with epilepsy
  • AA genotype and A allele of CYP2C19 G681A may be related to the occurrence and recurrence of cerebral ischemic stroke
  • AA genotype of rs10509676 was found more frequently in the hypertension group than in the control group
  • Candidate gene
    Marker
  • CYP2C19 polymorphism is associated with endometrisis and can be considered a potential biomarker of the disease
  • Therapy target
    ANIMAL & CELL MODELS