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FLASH GENE
Symbol CXCR3 contributors: mct - updated : 22-01-2016
HGNC name chemokine (C-X-C motif) receptor 3
HGNC id 4540
Location Xq13.1      Physical location : 70.835.766 - 70.838.367
Synonym name
  • chemokine receptor 3 for the interferon gamma inducible proteins INP10
  • IP10 receptor
  • G protein-coupled receptor 9
  • Mig receptor
  • CD183 antigen
    • Synonym symbol(s) GPR9, IP10, CD183, CKR-L2, CMKAR3, IP10-R, MigR, CD182
    DNA
    TYPE functioning gene
    STRUCTURE 2.60 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1914 - 415 - 2008 PMID: 188324
    inhibits cell growth
    - - - - - - 2004 PMID: 155283
  • also called CXCR3-alt
  • resulting from alternative splicing via exon skipping
  • localizes to the cell surface and mediates functional activity of CXCL11
    • 1 - 1670 40 368 - 2008 PMID: 188324
    promotes cell proliferation
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunenatural killer
    Lymphoid/ImmuneT cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • proximal 16 AAs residues of the N terminus required for CXCL10 and CXCL11 binding and activation but not CXCL9 activation
  • seven transmembrane segment (7TM) receptor
  • several extracellular loops
  • extracellular domains required for ligand binding and activation
  • C-terminus and third intracellular loop involved in receptor-mediated migration, adhesion and internalization in response to CXCL11
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Cxcr3 (83 pc)
    intraspecies homolog to IL8RA
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • chemokine receptor 3 for the interferon gamma inducible proteins INP10, MIG mediating a rapid induction of effector in T lymphocytes
  • chemokine receptor that plays important roles in mediating chemotactic signals and modulating the activation of lymphocytes
  • playing an important role in effector T-cell and NK cell trafficking
  • regulates the migration of Th1 lymphocytes and responds to three ligands: CXCL9, CXCL10, and CXCL11
  • plays an important role in T cell trafficking and function
  • role for CXCR3 in the trafficking of Th1 and CD8 T cells to peripheral sites of Th1-type inflammation
  • plays a role in the migration of T cells in the microenvironment of the peripheral tissue and lymphoid compartment, facilitating the interaction of T cells with antigen presenting cells leading to the generation of effector and memory cells
  • promotes epidermal tumorigenesis likely through a T-cell-dependent induction of keratinocyte proliferation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component CXCL9-CXCR3 regulates Th1-associated immune pathways in liver
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding CXCL9, CXCL10, CXCL11
  • induced by uveitis antigens in lymphocytes and immature dendritic cells
  • with its ligands, CXCL11, CXCL10, and CXCL9, play a major role in T-helper 1 (Th1)-dependent inflammatory responses
  • receptor of CXCL11 (key ligand in the CXCR3 signaling system for wound repair, promoting re-epithelialization and modulating the maturation of the superficial dermis)
  • KLF2 negatively controls the ability of CD8 T cells to respond to the CXCR3 ligand CXCL10
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary melanoma
    tumoral       gain of function
    of CXCR3 with its ligands stimulates colon cancer metastasis preferentially to the draining lymph nodes with poorer prognosis
    Susceptibility
  • to asthma
  • to childhood inflammatory bowel disease
    • Variant & Polymorphism other
  • (rs2280964G>A) associated with Asthma susceptibility
  • rs6817952 A variant is a risk allele for pediatric Crohn disease (CD) and ulcerative colitis (UC)
    • Candidate gene
    Marker
    Therapy target targeting CXCR3 splice variants or the signaling pathways downstream of CXCR3 receptors may provide a therapeutic strategy for the prevention of Calcineurin inhibitors -mediated renal cancer progression
    ANIMAL & CELL MODELS