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FLASH GENE
Symbol CXCR3 contributors: mct - updated : 22-01-2016
HGNC name chemokine (C-X-C motif) receptor 3
HGNC id 4540
DNA
TYPE functioning gene
STRUCTURE 2.60 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
SLC7A3 Xq12 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 LOC392488 X similar to Nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15) SNX12 Xq12-q13.1 sorting nexin 12 MLLT7 Xq13.1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 LOC158830 Xq13.1 similar to Ab2-183 IL2RG Xq12-q13.1 interleukin 2 receptor, gamma (severe combined immunodeficiency) TNRC11 Xq13 trinucleotide repeat containing 11 (THR-associated protein, 230kDa subunit) NLGN3 Xq13.1 neuroligin 3 GJB1 Xq13.1 gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked) ZNF261 Xq13.1 zinc finger protein 261 NONO Xq13.1 non-POU domain containing, octamer-binding ITGB1BP2 Xq12.1-q13 integrin beta 1 binding protein (melusin) 2 LOC392489 X similar to ras homolog gene family, member G (rho G); RhoG TAF1 Xq13.1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa ING2 Xq12 inhibitor of growth family, member 2 OGT Xq13 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) ACRC Xq13.1 acidic repeat containing CXCR3 Xq13 chemokine (C-X-C motif) receptor 3 LOC158825 Xq13.1 hypothetical LOC158825 LOC389868 X LOC389868 LOC389869 X LOC389869 LOC389870 X LOC389870 LOC389871 X LOC389871 LOC286539 Xq13.1 similar to 40S ribosomal protein S26 KIAA2001 Xq13.1 KIAA2001 protein LOC340527 Xq13.1 similar to Nance-Horan syndrome (congenital cataracts and dental anomalies); NHS gene LOC392490 X similar to Translationally controlled tumor protein (TCTP) (p23) (Histamine-releasing factor) (HRF) PIN4 Xq13 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) FLJ20105 Xq13.1 hypothetical protein FLJ20105 RPS4X Xq13.1 ribosomal protein S4, X-linked CITED1 Xq13.1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 HDAC8 Xq13 histone deacetylase 8
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1914 - 415 - 2008 PMID: 188324
inhibits cell growth
- - - - - - 2004 PMID: 155283
  • also called CXCR3-alt
  • resulting from alternative splicing via exon skipping
  • localizes to the cell surface and mediates functional activity of CXCL11
  • 1 - 1670 40 368 - 2008 PMID: 188324
    promotes cell proliferation
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunenatural killer
    Lymphoid/ImmuneT cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • proximal 16 AAs residues of the N terminus required for CXCL10 and CXCL11 binding and activation but not CXCL9 activation
  • seven transmembrane segment (7TM) receptor
  • several extracellular loops
  • extracellular domains required for ligand binding and activation
  • C-terminus and third intracellular loop involved in receptor-mediated migration, adhesion and internalization in response to CXCL11
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Cxcr3 (83 pc)
    intraspecies homolog to IL8RA
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • chemokine receptor 3 for the interferon gamma inducible proteins INP10, MIG mediating a rapid induction of effector in T lymphocytes
  • chemokine receptor that plays important roles in mediating chemotactic signals and modulating the activation of lymphocytes
  • playing an important role in effector T-cell and NK cell trafficking
  • regulates the migration of Th1 lymphocytes and responds to three ligands: CXCL9, CXCL10, and CXCL11
  • plays an important role in T cell trafficking and function
  • role for CXCR3 in the trafficking of Th1 and CD8 T cells to peripheral sites of Th1-type inflammation
  • plays a role in the migration of T cells in the microenvironment of the peripheral tissue and lymphoid compartment, facilitating the interaction of T cells with antigen presenting cells leading to the generation of effector and memory cells
  • promotes epidermal tumorigenesis likely through a T-cell-dependent induction of keratinocyte proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component CXCL9-CXCR3 regulates Th1-associated immune pathways in liver
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding CXCL9, CXCL10, CXCL11
  • induced by uveitis antigens in lymphocytes and immature dendritic cells
  • with its ligands, CXCL11, CXCL10, and CXCL9, play a major role in T-helper 1 (Th1)-dependent inflammatory responses
  • receptor of CXCL11 (key ligand in the CXCR3 signaling system for wound repair, promoting re-epithelialization and modulating the maturation of the superficial dermis)
  • KLF2 negatively controls the ability of CD8 T cells to respond to the CXCR3 ligand CXCL10
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary melanoma
    tumoral       gain of function
    of CXCR3 with its ligands stimulates colon cancer metastasis preferentially to the draining lymph nodes with poorer prognosis
    Susceptibility
  • to asthma
  • to childhood inflammatory bowel disease
  • Variant & Polymorphism other
  • (rs2280964G>A) associated with Asthma susceptibility
  • rs6817952 A variant is a risk allele for pediatric Crohn disease (CD) and ulcerative colitis (UC)
  • Candidate gene
    Marker
    Therapy target targeting CXCR3 splice variants or the signaling pathways downstream of CXCR3 receptors may provide a therapeutic strategy for the prevention of Calcineurin inhibitors -mediated renal cancer progression
    ANIMAL & CELL MODELS