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FLASH GENE
Symbol CXCR2 contributors: mct - updated : 29-04-2014
HGNC name chemokine (C-X-C motif) receptor 2
HGNC id 6027
Location 2q35      Physical location : 218.990.012 - 219.001.975
Synonym name
  • CXC chemokine receptor 2
  • interleukin 8 receptor, beta
  • high affinity interleukin-8 receptor B
  • GRO/MGSA receptor
  • CD182 antigen
  • Synonym symbol(s) IL8R2, CD182, IL8RA, CMKAR2, CDw128b, IL8RB, IL-8R B, CXC-R2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 11.23 kb     3 Exon(s)
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2880 40 360 - -
    - - 2672 - 360 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel     Homo sapiens
    Lymphoid/Immunespleen   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Connectiveadipose    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticneutrophil
    Lymphoid/Immunelymphocyte
    cell lineage adipose tissue-derived stem cells
    cell lines
    fluid/secretion predominantly and specific in blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM)
  • C-terminal type 1 PDZ ligand motif (-STTL) playing an essential role in both proper intracellular receptor trafficking and efficient cellular chemotaxis, acting to both delay lysosomal sorting and facilitating proper chemotactic response
  • HOMOLOGY
    interspecies homolog to rattus Il8rb (70.8 pc)
    homolog to murine Il8rb (71.3 pc)
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    text
  • multi-pass membrane protein
  • lysosomal shuttling of CXCR2 not dependent upon ubiquitination
  • both CXCL5 and CXCR2 were localized in the tunica intima and tunica adventitia of blood vessels in adipose tissue
  • basic FUNCTION
  • contributing to the temporal and spatial pattern of myelination in developing spinal cord (control of positioning of oligodendrocyte precursors)
  • acting as a receptor to interleukin-8, which is a powerful neutrophils chemotactic factor
  • acting as a rhodopsin-like receptor
  • plays an important role in many diverse physiological processes such as leukocyte chemotaxis, wound healing, angiogenesis, and inflammation
  • both CXCL1 and CXCR2 play an important role in chemokine expression and neutrophil infiltration following adenoviral corneal infection, but have a redundant role in the development of keratitis
  • CXCR1 and CXCR2 expression plays a critical role in regulating multiple biological activities in human microvascular endothelial cells
  • CXCR1 and CXCR2 are novel mechanosensors mediating laminar shear-stress-induced endothelial cell (EC) migration
  • critical role of the PDZ-dependent CXCR2 macromolecular signaling complex in regulating neutrophil functions
  • CXCR1 and CXCR2 couple to distinct GRK isoforms to mediate and regulate inflammatory responses
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS inflammation
    text positive regulation of cell proliferation
    PATHWAY
    metabolism
    signaling
    a component CXCL5/CXCR2 axis is likely responsible for the therapeutic effects via angiogenesis
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding GRO and NAP-2 (PPBP)
  • binding of IL-8
  • LASP1 interaction with CXCR2 is critical for CXCR2-mediated chemotaxis
  • CXCL5 exerts chemoattraction through CXCR2
  • SLC9A3R1 couples CXCR2 to its downstream effector phospholipase C (PLCB2), forming a macromolecular complex, through a PDZ-based interaction
  • interaction between SLC9A3R1 and CXCR2 or PLCB2 is PDZ motif-dependent
  • CXCR2 interacts with GRK6 to negatively regulate receptor sensitization and trafficking, thus affecting cell signaling and angiogenesis
  • IL8 plays a major role in neutrophil chemotaxis caused by alveolar macrophage-derived conditioned media, and this is most effectively inhibited by dual antagonism of CXCR1 and CXCR2
  • cell & other
    REGULATION
    induced by PPARG in human macrophages
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    observed in preneoplastic lesions
    constitutional     --over  
    in senescent cells
    tumoral     --low  
    or mutation may be necessary for progression of some cancer types
    Susceptibility to systemic sclerosis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    targeting the CXCR2 multiprotein complex may represent a novel therapeutic strategy for certain inflammatory diseases
    ANIMAL & CELL MODELS