basic FUNCTION
| contributing to the temporal and spatial pattern of myelination in developing spinal cord (control of positioning of oligodendrocyte precursors) |
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acting as a receptor to interleukin-8, which is a powerful neutrophils chemotactic factor |
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acting as a rhodopsin-like receptor |
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plays an important role in many diverse physiological processes such as leukocyte chemotaxis, wound healing, angiogenesis, and inflammation |
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both CXCL1 and CXCR2 play an important role in chemokine expression and neutrophil infiltration following adenoviral corneal infection, but have a redundant role in the development of keratitis |
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CXCR1 and CXCR2 expression plays a critical role in regulating multiple biological activities in human microvascular endothelial cells |
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CXCR1 and CXCR2 are novel mechanosensors mediating laminar shear-stress-induced endothelial cell (EC) migration |
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critical role of the PDZ-dependent CXCR2 macromolecular signaling complex in regulating neutrophil functions |
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CXCR1 and CXCR2 couple to distinct GRK isoforms to mediate and regulate inflammatory responses |
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CXCL1 and its receptor CXCR2 play a crucial role in host immune response by recruiting and activating neutrophils for microbial killing at the tissue site |