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FLASH GENE

Symbol

CXCL9

contributors: mct - updated : 04-10-2013

HGNC name	chemokine (C-X-C motif) ligand 9
HGNC id	7098

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4q21.1      Physical location : 76.922.622 - 76.928.641
Synonym name	monokine induced by gamma interferon
	small inducible cytokine B9
	C-X-C motif chemokine 9
Synonym symbol(s)	SCYB9, MIG, CMK, Humig, crg-10

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	6.02 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - IL8 - CXCL1 / PPBP / PF4 - CXCL5 / CXCL6 - CXCL2 / CXCL3 - CXCL11 - CXCL10 - CXCL9 - qter
Authors	O'Donovan et al. (99)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002416 4 - 2545 NP_002407 14 125 - 2007 PMID: 178755

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       highly Lymphoid/Immune spleen       highly   thymus       highly Reproductive male system testis     highly   male system male genital tract epididymis   highly   male system prostate     highly Respiratory respiratory tract trachea     highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Reproductive epithelial cell Skin/Tegument keratinocyte

cell lineage
cell lines
fluid/secretion	in seminal plasma

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

small inducible cytokine

HOMOLOGY

Homologene

FAMILY

intercrine alpha (chemokine CxC) family

CATEGORY

signaling cytokine

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	T cells and NK cells chemoattractant
	affecting the growth, movement, or activation state of cells that participate in immune and inflammatory response
	roles in both host defense of the male urogenital tract and during fertilization
	participate in immune and inflammatory responses through the chemoattraction and activation of polymorphonuclear neutrophils, T cells and B cells
	promotes CXCR3-dependent immune-mediated kidney disease
	recruit donor-reactive T cells to the allograft, and promotes the development of IFN-gamma-producing CD8 T cells
	has immunomodulatory functions that are not mediated through a G-protein coupled receptor and may possess additional roles in host defenses against infection

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

CXCL9-CXCR3 regulates Th1-associated immune pathways in liver

INTERACTION

DNA

RNA

small molecule

protein	interacts with the receptor CXCR3, which also binds two other structurally related ligands: IFN-gamma-inducible protein CXCL10, CXCL11
	CXCL9 was involved in the invasion ability of hepatocellular carcinoma possibly through up-regulation of its potential effector PREX2

cell & other

REGULATION

induced by

interferon gamma inducible

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in colonic tissues of Crohn's disease (CD) and ulcerative colitis (UC)

Susceptibility

to Crohn disease (CD) and ulcerative colitis (UC)

Variant & Polymorphism SNP	increasing the risk of Crohn disease

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS