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FLASH GENE
Symbol CXCL9 contributors: mct - updated : 04-10-2010
HGNC name chemokine (C-X-C motif) ligand 9
HGNC id 7098
Location 4q21.1      Physical location : 76.922.622 - 76.928.641
Synonym name
  • monokine induced by gamma interferon
  • small inducible cytokine B9
  • C-X-C motif chemokine 9
  • Synonym symbol(s) SCYB9, MIG, CMK, Humig, crg-10
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 6.02 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - IL8 - CXCL1 / PPBP / PF4 - CXCL5 / CXCL6 - CXCL2 / CXCL3 - CXCL11 - CXCL10 - CXCL9 - qter
    Authors O'Donovan et al. (99)
    Physical map
    AREG 4q13-q21 amphiregulin (schwannoma-derived growth factor) BTC 4q13-q21 betacellulin DKFZP564O0823 4q13.3-q21.3 DKFZP564O0823 protein FLJ23604 4q21.21 hypothetical protein FLJ23604 ZNF363 4q21.1 zinc finger protein 363 THAP6 4q21.21 THAP domain containing 6 FLJ23657 4q21.21 hypothetical protein FLJ23657 CDKL2 4q21.21 cyclin-dependent kinase-like 2 (CDC2-related kinase) G3BP2 4q12-q21.1 cyclin-dependent kinase-like 2 (CDC2-related kinase) VDP 4q21.1 vesicle docking protein p115 PPEF2 4q13-q21 protein phosphatase, EF hand calcium-binding domain 2 ASAHL 4q21.1 N-acylsphingosine amidohydrolase (acid ceramidase)-like FLJ10498 4q21.21 hypothetical protein FLJ10498 CXCL9 4q21.2 chemokine (C-X-C motif) ligand 9 CXCL10 4q21.2 chemokine (C-X-C motif) ligand 10 CXCL11 4q21.2 chemokine (C-X-C motif) ligand 11 ART3 4p15.1-p14 ADP-ribosyltransferase 3 NUP54 4q21.1 nucleoporin 54kDa SCARB2 4q21.1 scavenger receptor class B, member 2 GENX-3414 4q24-q25 genethonin 1 FLJ25770 4q21.22 hypothetical protein FLJ25770 ShrmL 4q21.22 Shroom-related protein LOC152825 4q21.22 similar to ribosomal protein L26 LOC345079 4q21.22 similar to RIKEN cDNA 5730467H21 FLJ10849 4q21.22 hypothetical protein FLJ10849 AF357530 4q21.1 thioredoxin 1 pseudogene 3 CCNI 4pter-qter cyclin I LOC339966 4q21.22 similar to Gene product with similarity to Ubiquitin binding enzyme CCNG2 4q21.22 cyclin G2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2545 14 125 - 2007 PMID: 178755
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    Reproductivemale systemtestis  highly
     male systemmale genital tractepididymis highly
     male systemprostate  highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Reproductiveepithelial cell
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion in seminal plasma
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    small inducible cytokine
    HOMOLOGY
    Homologene
    FAMILY
  • intercrine alpha (chemokine CxC) family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • T cells and NK cells chemoattractant
  • affecting the growth, movement, or activation state of cells that participate in immune and inflammatory response
  • roles in both host defense of the male urogenital tract and during fertilization
  • participate in immune and inflammatory responses through the chemoattraction and activation of polymorphonuclear neutrophils, T cells and B cells
  • promotes CXCR3-dependent immune-mediated kidney disease
  • recruit donor-reactive T cells to the allograft, and promotes the development of IFN-gamma-producing CD8 T cells
  • has immunomodulatory functions that are not mediated through a G-protein coupled receptor and may possess additional roles in host defenses against infection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component CXCL9-CXCR3 regulates Th1-associated immune pathways in liver
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the receptor CXCR3, which also binds two other structurally related ligands: IFN-gamma-inducible protein CXCL10, CXCL11
  • cell & other
    REGULATION
    induced by interferon gamma inducible
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in colonic tissues of Crohn's disease (CD) and ulcerative colitis (UC)
    Susceptibility
  • to Crohn disease (CD) and ulcerative colitis (UC)
  • Variant & Polymorphism SNP increasing the risk of Crohn disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS