Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CXCL9 contributors: mct - updated : 04-10-2013
HGNC name chemokine (C-X-C motif) ligand 9
HGNC id 7098
Location 4q21.1      Physical location : 76.922.622 - 76.928.641
Synonym name
  • monokine induced by gamma interferon
  • small inducible cytokine B9
  • C-X-C motif chemokine 9
  • Synonym symbol(s) SCYB9, MIG, CMK, Humig, crg-10
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 6.02 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - IL8 - CXCL1 / PPBP / PF4 - CXCL5 / CXCL6 - CXCL2 / CXCL3 - CXCL11 - CXCL10 - CXCL9 - qter
    Authors O'Donovan et al. (99)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2545 14 125 - 2007 PMID: 178755
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    Reproductivemale systemtestis  highly
     male systemmale genital tractepididymis highly
     male systemprostate  highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Reproductiveepithelial cell
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion in seminal plasma
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    small inducible cytokine
    HOMOLOGY
    Homologene
    FAMILY
  • intercrine alpha (chemokine CxC) family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • T cells and NK cells chemoattractant
  • affecting the growth, movement, or activation state of cells that participate in immune and inflammatory response
  • roles in both host defense of the male urogenital tract and during fertilization
  • participate in immune and inflammatory responses through the chemoattraction and activation of polymorphonuclear neutrophils, T cells and B cells
  • promotes CXCR3-dependent immune-mediated kidney disease
  • recruit donor-reactive T cells to the allograft, and promotes the development of IFN-gamma-producing CD8 T cells
  • has immunomodulatory functions that are not mediated through a G-protein coupled receptor and may possess additional roles in host defenses against infection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component CXCL9-CXCR3 regulates Th1-associated immune pathways in liver
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the receptor CXCR3, which also binds two other structurally related ligands: IFN-gamma-inducible protein CXCL10, CXCL11
  • CXCL9 was involved in the invasion ability of hepatocellular carcinoma possibly through up-regulation of its potential effector PREX2
  • cell & other
    REGULATION
    induced by interferon gamma inducible
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in colonic tissues of Crohn's disease (CD) and ulcerative colitis (UC)
    Susceptibility
  • to Crohn disease (CD) and ulcerative colitis (UC)
  • Variant & Polymorphism SNP increasing the risk of Crohn disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS