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FLASH GENE
Symbol CTSH contributors: mct/shn - updated : 07-07-2014
HGNC name cathepsin H
HGNC id 2535
Location 15q25.1      Physical location : 79.214.091 - 79.237.420
Synonym name
  • N-benzoylarginine-beta-naphthylamide hydrolase
  • aleurain
  • cathepsin BA
  • cathepsin B3
  • Synonym symbol(s) CPSB, minichain, ACC-4, ACC-5, MGC1519, DKFZp686B24257
    EC.number 3.4.22.16
    DNA
    TYPE functioning gene
    STRUCTURE 23.34 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D15S1027 - D15S1023 - CTSH - D15S989 - D15S1005 - qter
    Physical map
    LOC146013 15q24.1 similar to SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain containing adapter protein) KIP2 15q24.3 similar to SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain containing adapter protein) IDH3A 15q25.1-q25.2 isocitrate dehydrogenase 3 (NAD+) alpha BG1 15q24-q25 isocitrate dehydrogenase 3 (NAD+) alpha DNAJA4 15q24.1 DnaJ (Hsp40) homolog, subfamily A, member 4 REC14 15q24.1 recombination protein REC14 CRABP1 15q24 cellular retinoic acid binding protein 1 IREB2 15q24 iron-responsive element binding protein 2 LOC123688 15q24.1 similar to RIKEN cDNA C630028N24 gene PSMA4 15q24.1 proteasome (prosome, macropain) subunit, alpha type, 4 CHRNA5 15q24 cholinergic receptor, nicotinic, alpha polypeptide 5 CHRNA3 15q24 cholinergic receptor, nicotinic, alpha polypeptide 3 CHRNB4 15q24 cholinergic receptor, nicotinic, beta polypeptide 4 LOC390612 15 similar to ribosomal protein L18; 60S ribosomal protein L18 LOC388142 15 LOC388142 LOC390613 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) ADAMTS7 15pter-qter a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7 LOC390614 15 similar to cDNA sequence BC053073; G-protein coupled receptor SALPR; somatostatin and angiotensin-like peptide receptor LOC388143 15 similar to 60S ribosomal protein L21 MORF4L1 15q24 mortality factor 4 like 1 CTSH 15q24-q25 cathepsin H RASGRF1 15q24 Ras protein-specific guanine nucleotide-releasing factor 1 LOC390615 15 similar to HNRPC protein LOC390616 15 similar to RIKEN cDNA 6430502M16 gene P24B 15q24-q25 integral type I protein KIAA1024 15q24.2 KIAA1024 protein LOC390617 15 similar to Transcription factor DP-1 (E2F dimerization partner 1) (DRTF1-polypeptide-1) (DRTF1) LOC390618 15 similar to ribosomal protein L7-like 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1494 41 335 - 2003 1451599
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestivestomach   highly
    Endocrineparathyroid   moderately
    Lymphoid/Immunelymph node   highly
     tonsils   moderately
    Respiratorylung   moderately
    Urinarybladder   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a dimer of disulfide-linked heavy and light chains
  • N-terminal head domain (residues 1400), which includes the principal integrin-binding site,
  • a large C-terminal rod domain (residues 4822541), which contains lateral integrin-binding sites and binding sites
  • mono polymer heteromer , dimer
    isoforms Precursor synthesized as an inactive precursor and activated by proteolytic removal of its propeptide
    HOMOLOGY
    interspecies ortholog to Ctsh, Mus musculus
    ortholog to CTSH, Pan troglodytes
    ortholog to Ctsh, Rattus norvegicus
    ortholog to ctsh, Danio rerio
    Homologene
    FAMILY
  • peptidase C1 protein family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lysosome
    text
  • requires exclusively sortilin for its transport to the lysosomes
  • in secretory vesicles that produces (Met)enkephalin (ME)
  • basic FUNCTION
  • cysteine proteinase, involved in matrix degradation during endochondral ossification
  • lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins
  • acting both as an aminopeptidase and as an endopeptidase
  • involved in maturation of the biologically active Surfactant protein B peptide
  • may play a role in the activation of an adoptive immune response
  • specific role for CTSH in the pleural host response
  • has proGrB convertase activity in vitro
  • role for CTSH as an aminopeptidase for enkephalin and galanin peptide neurotransmitter production
  • unique member of the cysteine cathepsins that acts primarily as an aminopeptidase
  • aminopeptidase that is involved in tumor progression
  • role for this cathepsin in the axial length determination
  • is an important regulator of beta-cell function during progression of Type 1 diabetes
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimer of disulfide-linked heavy and light chains
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cystatin A (stefin A), CSTA 5 (
  • talin is a substrate for cathepsin H (CTSH), a lysosomal cysteine protease with a strong aminopeptidase activity
  • affects cell migration by influencing the activity of integrins, a process that could be regulated by talin cleavage
  • CTSH-mediated processing of TLN1 might promote cancer cell progression by affecting integrin activation and adhesion strength
  • TLN1 is a specific substrate of CTSH that could be associated with regulation of ITGB3 receptors, focal adhesion (FA) strength, and cell migration
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    increased expression correlated with malignant progression of prostate tumors
    constitutional       loss of function
    in severe myopia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking both CatC and CatH expression have cytotoxic lymphocytes with reduced convertase activity
  • cathepsin H deficient mice also show a substantial decrease in galanin peptide neurotransmitter levels in brain