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FLASH GENE

Symbol

CTSH

contributors: mct/shn - updated : 07-07-2014

HGNC name	cathepsin H
HGNC id	2535

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   increased expression correlated with malignant progression of prostate tumors constitutional       loss of function in severe myopia

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	mice lacking both CatC and CatH expression have cytotoxic lymphocytes with reduced convertase activity
	cathepsin H deficient mice also show a substantial decrease in galanin peptide neurotransmitter levels in brain