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FLASH GENE
Symbol CTRC contributors: mct - updated : 09-02-2008
HGNC name chymotrypsin C (caldecrin)
HGNC id 2523
Location 1p36.21      Physical location : 15.764.937 - 15.773.153
Synonym name
  • serum calcium decreasing factor
  • caldecrin
  • elastase 4
  • elastase IV
  • Synonym symbol(s) CLCR, ELA4
    EC.number 3.4.21.2
    DNA
    TYPE functioning gene
    STRUCTURE 8.00 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391006 1 similar to beta-tubulin cofactor A KIAA1026 1p36.13 KIAA1026 protein FLJ23703 1p36.13 hypothetical protein FLJ23703 FLJ10199 1p36.13 hypothetical protein FLJ10199 KIAA1937 1p36.13 KIAA1937 protein MGC4342 CTRC 1p36.13 chymotrypsin C (caldecrin) ELA2A 1p36.13 elastase 2A ELA2B 1p36.13 pancreatic elastase IIB CASP9 1p36.3-p36.1 caspase 9, apoptosis-related cysteine protease KIAA0962 1p36.1 caspase 9, apoptosis-related cysteine protease AGMAT 1p36.13 agmatine ureohydrolase (agmatinase) LOC284722 1p36.13 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein DDI2 1p36.13 DNA-damage inducible protein 2 RSC1A1 1p36.1 regulatory solute carrier protein, family 1, member 1 KIAA0842 1p36.13 KIAA0842 protein LOC388595 1 similar to Hypothetical protein MGC37938 FBLP-1 1p36.13 filamin-binding LIM protein-1 LOC391007 1 similar to 60S ribosomal protein L12 LOC388596 1 similar to 40S ribosomal protein S16 SHARP 1p36.33-p36.11 similar to 40S ribosomal protein S16 ZNF151 1p36.1 zinc finger protein 151 (pHZ-67) MGC24047 1p36.13 hypothetical protein MGC24047 HSPB7 1p36.23-p34.3 heat shock 27kDa protein family, member 7 (cardiovascular) CLCNKA 1p36 chloride channel Ka CLCNKB 1p36.1 chloride channel Kb FLJ36766 1p36.13 hypothetical protein FLJ36766 EPHA2 1p36.1 EphA2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 917 - 268 - Rosendahl (2008)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Lymphoid/Immunespleen    
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion serum
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    trypsin like serine protease
    HOMOLOGY
    Homologene
    FAMILY petidase family S1
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • serum calcium decreasing factor
  • degrades all trypsin and trypsinogen isoforms with high specificity
  • key regulator of activation and degradation of cationic trypsin (in the high Ca(2+) environment of the duodenum, facilitates trypsinogen activation, whereas in the lower intestines, promotes trypsin degradation as a function of decreasing luminal Ca(2+) concentrations)
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    Ca2++
    protein
  • CTRC is a physiological co-activator of proCPA1 and proCPA2 and is a key regulator of digestive zymogen activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to chronic pancreatitis
    Variant & Polymorphism other loss-of-function alterations predispose to pancreatitis by diminishing its protective trypsin-degrading activity
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS