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FLASH GENE

Symbol

CTRC

contributors: mct - updated : 09-02-2008

HGNC name	chymotrypsin C (caldecrin)
HGNC id	2523

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p36.21      Physical location : 15.764.937 - 15.773.153
Synonym name	serum calcium decreasing factor
	caldecrin
	elastase 4
	elastase IV
Synonym symbol(s)	CLCR, ELA4
EC.number	3.4.21.2

DNA

TYPE	functioning gene
STRUCTURE	8.00 kb     8 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 8 - 917 - 268 - Rosendahl (2008)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Endocrine pancreas         Lymphoid/Immune spleen         Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular exocrine

cell lineage
cell lines
fluid/secretion	serum

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

trypsin like serine protease

HOMOLOGY

Homologene

FAMILY

petidase family S1

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

basic FUNCTION	serum calcium decreasing factor
	degrades all trypsin and trypsinogen isoforms with high specificity
	key regulator of activation and degradation of cationic trypsin (in the high Ca(2+) environment of the duodenum, facilitates trypsinogen activation, whereas in the lower intestines, promotes trypsin degradation as a function of decreasing luminal Ca(2+) concentrations)

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule
	Ca2++

protein

CTRC is a physiological co-activator of proCPA1 and proCPA2 and is a key regulator of digestive zymogen activation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to chronic pancreatitis

Variant & Polymorphism other	loss-of-function alterations predispose to pancreatitis by diminishing its protective trypsin-degrading activity

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS