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FLASH GENE
Symbol CTRC contributors: mct - updated : 09-02-2008
HGNC name chymotrypsin C (caldecrin)
HGNC id 2523
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     8 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 917 - 268 - Rosendahl (2008)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinepancreas    
Lymphoid/Immunespleen    
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion serum
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
trypsin like serine protease
HOMOLOGY
Homologene
FAMILY petidase family S1
CATEGORY enzyme
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • serum calcium decreasing factor
  • degrades all trypsin and trypsinogen isoforms with high specificity
  • key regulator of activation and degradation of cationic trypsin (in the high Ca(2+) environment of the duodenum, facilitates trypsinogen activation, whereas in the lower intestines, promotes trypsin degradation as a function of decreasing luminal Ca(2+) concentrations)
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    Ca2++
    protein
  • CTRC is a physiological co-activator of proCPA1 and proCPA2 and is a key regulator of digestive zymogen activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to chronic pancreatitis
    Variant & Polymorphism other loss-of-function alterations predispose to pancreatitis by diminishing its protective trypsin-degrading activity
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS