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FLASH GENE
Symbol CTNNA2 contributors: mct - updated : 09-06-2012
HGNC name catenin (cadherin-associated protein), alpha 2
HGNC id 2510
Location 2p12      Physical location : 79.740.059 - 80.875.986
Synonym name
  • alpha N-catenin, neural
  • cadherin-associated protein, related
  • Synonym symbol(s) CAPR, CATNA2, CTNR, CTN2, CAP-R, CT114
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene
    text
  • CTNNA genes contain antisense oriented leucine rich repeat transmembrane (LRRTM) genes within their seventh introns (CTNNA2 containing LRRTM1)
  • STRUCTURE 1135.93 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • share bidirectional promoters with LRRTM1
  • novel 5prime exon VIIb containing CTNNA2 mRNAs are expressed almost exclusively in the nervous system
  • MAPPING cloned Y linked N status provisional
    Physical map
    DOK1 2p13 docking protein 1, 62kDa (downstream of tyrosine kinase 1) LOC130951 2p13.1 hypothetical protein BC014602 SEMA4F 2p13 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F HK2 2p13.1 hexokinase 2 POLE4 2p12 polymerase (DNA-directed), epsilon 4 (p12 subunit) TACR1 2p13-p11 tachykinin receptor 1 LOC388964 2 LOC388964 FLJ13391 2p12 hypothetical protein FLJ13391 MRPL19 2q11.1-q11.2 mitochondrial ribosomal protein L19 C2orf3 2p11.2-p11.1 chromosome 2 open reading frame 3 LOC150610 2p12 similar to Purine nucleoside phosphorylase (Inosine phosphorylase) (PNP) LRRTM4 2p12 similar to Purine nucleoside phosphorylase (Inosine phosphorylase) (PNP) HCP6 2p12 cytochrome c, somatic pseudogene UNQ429 2p12 LPPM429 REG1B 2p12 regenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein) REG1A 2p12 regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein) REGL 2p12 regenerating islet-derived-like, pancreatic stone protein-like, pancreatic thread protein-like (rat) PAP 2p12 pancreatitis-associated protein CTNNA2 2p12-p11.1 catenin (cadherin-associated protein), alpha 2 LRRTM1 2p12 catenin (cadherin-associated protein), alpha 2 LOC388965 2 similar to hepatitis C virus core-binding protein 6; cervical cancer oncogene 3 SUCLG1 2p11.2 succinate-CoA ligase, GDP-forming, alpha subunit FLJ37357 2p11.2 hypothetical protein FLJ37357
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 3870 - 860 - 2011 21708131
    18 - 4005 - 905 widely expressed, expressed in all brain regions analyzed with higher levels in the olfactory tract, frontal lobe, infundibulum, cerebellum, ventral pons and caudate nucleus 2011 21708131
    CTNNA2A
    - - 2900 59.9 537 very high expression levels in the olfactory bulb, frontal, occipital and parietal cortex, infundibulum, corpus mammilare, dorsal medulla, hippocampus, amygdala, thalamus and pineal gland, and expressed at lower levels in several other brain regions, detectable at significantly lower levels in the cerebellum and liver 2011 21708131
    EXPRESSION
    Rna function mRNAs were abundant in both dorsolateral prefrontal cortex and hippocampus, with a distinct neuronal localization, and also abundant in the granule cells of the dentate gyrus and pyramidal cells of Ammon horn
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral cortexfrontal cortexhighly Homo sapiens
     brainlimbic systemhippocampus   Homo sapiens
     nerve     Homo sapiens
    Reproductivemale systemtestis   
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervouspyramidal cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Catna2
    intraspecies homolog to vinculin
    Homologene
    FAMILY vinculin family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,desmosome
        intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • regulating cell adhesion and linking classical cadherins to the neuronal cytoskeleton
  • thought to play a major role in the folding and lamination of the cerebral cortex
  • cadherin-binding protein, widely expressed in the nervous system and playing a crucial role in cadherin-mediated cell-cell adhesion
  • has diverse roles in the organization of the central nervous system, but only in limited portions of the brain
  • essential for the regulation of cell–cell and cell–matrix interactions in tissues
  • regulates the structure of synaptic contacts and is essential for normal brain development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of the E cadherin multiprotein complex
  • s2 constituent of desmosomal plaque
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    significant decrease in expression among patient non-smokers compared to smokers, schizophrenic or not
    constitutional     --over  
    in the degeneration/regeneration processes of the muscle after nerve injury
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • promising candidate gene for schizophrenia
  • Marker
    Therapy target
    ANIMAL & CELL MODELS