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FLASH GENE
Symbol CTNNA2 contributors: mct - updated : 09-06-2012
HGNC name catenin (cadherin-associated protein), alpha 2
HGNC id 2510
EXPRESSION
Rna function mRNAs were abundant in both dorsolateral prefrontal cortex and hippocampus, with a distinct neuronal localization, and also abundant in the granule cells of the dentate gyrus and pyramidal cells of Ammon horn
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortexfrontal cortexhighly Homo sapiens
 brainlimbic systemhippocampus   Homo sapiens
 nerve     Homo sapiens
Reproductivemale systemtestis   
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Nervouspyramidal cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Catna2
intraspecies homolog to vinculin
Homologene
FAMILY vinculin family
CATEGORY adhesion
SUBCELLULAR LOCALIZATION     plasma membrane,junction,desmosome
    intracellular
intracellular,cytoplasm,cytoskeleton
basic FUNCTION
  • regulating cell adhesion and linking classical cadherins to the neuronal cytoskeleton
  • thought to play a major role in the folding and lamination of the cerebral cortex
  • cadherin-binding protein, widely expressed in the nervous system and playing a crucial role in cadherin-mediated cell-cell adhesion
  • has diverse roles in the organization of the central nervous system, but only in limited portions of the brain
  • essential for the regulation of cell–cell and cell–matrix interactions in tissues
  • regulates the structure of synaptic contacts and is essential for normal brain development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of the E cadherin multiprotein complex
  • s2 constituent of desmosomal plaque
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    significant decrease in expression among patient non-smokers compared to smokers, schizophrenic or not
    constitutional     --over  
    in the degeneration/regeneration processes of the muscle after nerve injury
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • promising candidate gene for schizophrenia
  • Marker
    Therapy target
    ANIMAL & CELL MODELS