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FLASH GENE
Symbol CSNK2B contributors: mct - updated : 03-07-2012
HGNC name casein kinase 2, beta polypeptide
HGNC id 2460
Location 6p21.33      Physical location : 2.919.235 - 31.637.843
Synonym symbol(s) CK2B,G5A, CK2N, CSK2B, MGC138222, MGC138224
EC.number 2.7.1.37/ 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 4.19 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
text structure three transcription initiation site CpG island
MAPPING cloned Y linked   status confirmed
Map see PKHD1
Physical map
HCP5 6p21.3 HLA complex P5 MICB 6p21.3 MHC class I polypeptide-related sequence B PPIP9 6p21.3 peptidylprolyl isomerase (cyclophilin) pseudogene 9 BAT1 6p21.33 HLA-B associated transcript 1 ATP6V1G2 6p21.3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 2 NFKBIL1 6p21.3 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 LTA 6p21.3 lymphotoxin alpha (TNF superfamily, member 1) TNF 6p21.3 tumor necrosis factor (TNF superfamily, member 2) LTB 6p21.3 lymphotoxin beta (TNF superfamily, member 3) LST1 6p21.3 leukocyte specific transcript 1 NCR3 6p21.3 natural cytotoxicity triggering receptor 3 AIF1 6p21.3 allograft inflammatory factor 1 BAT2 6p21.33 HLA-B associated transcript 2 BAT3 6p21.33 HLA-B associated transcript 3 APOM 6p21.31 apolipoprotein M C6orf47 6p21.3 chromosome 6 open reading frame 47 BAT4 6p21.33 HLA-B associated transcript 4 CSNK2B 6p21.3 casein kinase 2, beta polypeptide LY6G5B 6p21.3 lymphocyte antigen 6 complex, locus G5B LY6G5C 6p21.3 lymphocyte antigen 6 complex, locus G5C BAT5 6p21.33 HLA-B associated transcript 5 LY6G6D 6p21.3 lymphocyte antigen 6 complex, locus G6D LY6G6E 6p21.3 lymphocyte antigen 6 complex, locus G6E LY6G6C 6p21.3 lymphocyte antigen 6 complex, locus G6C C6orf25 6p21.3 chromosome 6 open reading frame 25 DDAH2 6p21.3 dimethylarginine dimethylaminohydrolase 2 CLIC1 6p21.3 chloride intracellular channel 1 MSH5 6p21.3 mutS homolog 5 (E. coli) C6orf27 6p21.31 chromosome 6 open reading frame 27 VARS2 6p21.3 valyl-tRNA synthetase 2 LSM2 6p21.3 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) HSPA1L 6p21.3 heat shock 70kDa protein 1-like HSPA1A 6p21.3 heat shock 70kDa protein 1A HSPA1B 6p21.3 heat shock 70kDa protein 1B
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1128 - 215 - 1999 10357806
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   moderately
 stomach   moderately
Endocrineparathyroid   moderately
Lymphoid/Immunelymph node   moderately
 tonsils   highly
Reproductivefemale systemuteruscervix moderately
 female systemovary  moderately
 female systemplacenta  moderately
Skin/Tegumentskin   moderately
Visualeye   moderately
cell lineage
cell lines
fluid/secretion
  • blood
  • at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a zinc binding region for dimerization
  • conjugated PhosphoP
    mono polymer heteromer , tetramer , complex
    HOMOLOGY
    interspecies homolog to rattus Csnk2b (100.00 pc)
    homolog to murine Csnk2b (100.00 pc)
    homolog to drosophila CkIIbeta (89.15 pc)
    Homologene
    FAMILY casein kinase 2 subunit beta family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • not a casein kinase in vivo, likely involved in regulation of cell growth
  • may be involved in cell proliferation through GADD45GIP1 phosphorylation
  • role in cell proliferation and anchorage-independent cell growth
  • required for CADPS activity
  • novel enhancer of ACVRL1 signaling, and important regulator of ACVRL1 signaling and ACVRL1-mediated functions in endothelial cells
  • participates in PLK1-WEE1 complex formation interacting directly with WEE1 and thereby contributing to the regulation of G2-M cell cycle transition)
  • negative regulator of BMP signaling and osteoblast differentiation
  • might control neurotransmitter release by acting on SNARE proteins attached to cholesterol-enriched microdomains
  • crucial protein involved in the formation and clearance of aggresomes, and hence in cell viability in response to misfolded protein stress
  • participates in the regulation of fundamental cellular processes
  • CELLULAR PROCESS cell cycle, division
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text insulin mediated cell metabolism and growth
    PATHWAY
    metabolism
    signaling signal transduction
    ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication
    a component
  • a heterotetramer (2A,2B) complexing with the FACT elongation transcription factor made of SSRP1 and FACTP140
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GADD45GIP1
  • CSNK2A1
  • CSNK2A2
  • LYN
  • MBD4
  • RPL5
  • ZNF44
  • ZNHIT1
  • ACVRL1/CSNK2B interaction specifically enhanced Smad1/5/8 phosphorylation
  • interacting with TNFAIP1 (CSNK2B could phosphorylate TNFAIP1, which facilitated the distribution of TNFAIP1 in nucleus and enhanced its interaction with PCNA)
  • binding and regulatory partner for RPS6KA5
  • BMP receptor type Ia (BMPR1A) interacting protein
  • crucial modulator of HDAC6 activity because CSNK2B directly phosphorylates HDAC6 and increases cytoplasmic deacetylase activity
  • interaction partner of the adiponectin receptor 1 (ADIPOR1) N-terminus (interaction of ADIPOR1 with the tetrameric complex and CSNK2B is as a key player in adiponectin signaling)
  • cell & other
    REGULATION
    Other phosphorylated by the alpha chain
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    dysregulation of CSNK2B expression might contribute to epithelial to mesenchymal transition induction during cancer progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS