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FLASH GENE
Symbol CSNK2B contributors: mct - updated : 03-07-2012
HGNC name casein kinase 2, beta polypeptide
HGNC id 2460
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a zinc binding region for dimerization
  • conjugated PhosphoP
    mono polymer heteromer , tetramer , complex
    HOMOLOGY
    interspecies homolog to rattus Csnk2b (100.00 pc)
    homolog to murine Csnk2b (100.00 pc)
    homolog to drosophila CkIIbeta (89.15 pc)
    Homologene
    FAMILY casein kinase 2 subunit beta family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • not a casein kinase in vivo, likely involved in regulation of cell growth
  • may be involved in cell proliferation through GADD45GIP1 phosphorylation
  • role in cell proliferation and anchorage-independent cell growth
  • required for CADPS activity
  • novel enhancer of ACVRL1 signaling, and important regulator of ACVRL1 signaling and ACVRL1-mediated functions in endothelial cells
  • participates in PLK1-WEE1 complex formation interacting directly with WEE1 and thereby contributing to the regulation of G2-M cell cycle transition)
  • negative regulator of BMP signaling and osteoblast differentiation
  • might control neurotransmitter release by acting on SNARE proteins attached to cholesterol-enriched microdomains
  • crucial protein involved in the formation and clearance of aggresomes, and hence in cell viability in response to misfolded protein stress
  • participates in the regulation of fundamental cellular processes
  • CELLULAR PROCESS cell cycle, division
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text insulin mediated cell metabolism and growth
    PATHWAY
    metabolism
    signaling signal transduction
    ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication
    a component
  • a heterotetramer (2A,2B) complexing with the FACT elongation transcription factor made of SSRP1 and FACTP140
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GADD45GIP1
  • CSNK2A1
  • CSNK2A2
  • LYN
  • MBD4
  • RPL5
  • ZNF44
  • ZNHIT1
  • ACVRL1/CSNK2B interaction specifically enhanced Smad1/5/8 phosphorylation
  • interacting with TNFAIP1 (CSNK2B could phosphorylate TNFAIP1, which facilitated the distribution of TNFAIP1 in nucleus and enhanced its interaction with PCNA)
  • binding and regulatory partner for RPS6KA5
  • BMP receptor type Ia (BMPR1A) interacting protein
  • crucial modulator of HDAC6 activity because CSNK2B directly phosphorylates HDAC6 and increases cytoplasmic deacetylase activity
  • interaction partner of the adiponectin receptor 1 (ADIPOR1) N-terminus (interaction of ADIPOR1 with the tetrameric complex and CSNK2B is as a key player in adiponectin signaling)
  • cell & other
    REGULATION
    Other phosphorylated by the alpha chain
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    dysregulation of CSNK2B expression might contribute to epithelial to mesenchymal transition induction during cancer progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS