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FLASH GENE
Symbol CSNK2A1 contributors: mct - updated : 26-02-2015
HGNC name casein kinase 2, alpha 1 polypeptide
HGNC id 2457
Location 20p15.3      Physical location : 463.337 - 524.482
Synonym name
  • CK2 catalytic subunit alpha
  • protein kinase CK2
    • Synonym symbol(s) CK2A2, CKII, CK2A1, CKII alpha, CK2
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 61.15 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    motif repetitive sequence   ALU
    text structure multiple initiation sites
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 splicing 2849 45.14 391 - 1998 9503018
  • also called variant 1/isoform a
  • encoding the same protein than variant 2
  • 14 exons
    • 13 splicing 2732 45.14 391 - 1998 9503018
  • also called variant 2/isoform a
  • differing in the 5' UTR compared to variant 1 (13 exons)
  • lacking exon 2
  • encoding the same protein than variant 1
    • 12 splicing 2522 29 255 - 1998 9503018
  • also called variant 3/isoform b
  • lacking an alternate exon in the 5' UTR as well as the first coding exon compared to variant 1 (12 exons)
    		•
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     liver   moderately
     mouthtongue  highly
    Endocrineneuroendocrinepituitary  moderately
    Lymphoid/Immunelymph node   moderately
    Nervousbrain   highly
     nerve   moderately
    Reproductivemale systemtestis  moderately
    Respiratoryrespiratory tractlarynx  highly
     respiratory tracttrachea  moderately
    Urinarykidney   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  moderately
    Muscular   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a protein kinase domain
  • C-terminus required for mitotic spindle localization
    • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Csnk2a1 (98.47 pc)
    homolog to murine Csnk2a1 (98.72 pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • CK2 subfamily
    • CATEGORY enzyme , receptor membrane serine/threonine kinase
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • localizes to the mitotic spindle in a phosphorylation-dependent manner
    • basic FUNCTION
  • involved in regulation of cell growth
  • serine/threonine kinase
  • also putative target and regulator of RaF/MAPK signaling
  • regulates the DNA-binding ability of SSRP1 and this regulation may be responsive to specific cell stresses
  • acting as an inhibitor of Cdk5 in the brain
  • phosphorylating NAP1L1 (appears to regulate NAP1L1 localization and is required for normal progression through S phase)
  • is involved in the regulation of RNA processing
  • CSNK2A1 and PRPF3 are absolutely necessary for an efficient splicing whereas CSNK2A2 seems to be dispensable
  • promoting survival in cancer by increasing survivin expression via beta-catenin-TCF/LEF-mediated transcription
  • essential regulator of the circadian system
  • CSNK2A1-dependent phosphorylation of CLIP1 is involved in its dynactin-dependent kinetochore localization during mitosis
  • implicated in the insulin regulation on pancreatic beta-cells (
  • with CSNK2A1, plays an important role in regulating nuclear ERK activities
  • regulates the expression of IL6
  • CSNK2A1 is an upstream activating kinase of PAK1, providing a novel mechanism for PAK1 activation
  • plays a regulatory role in many cellular events, particularly, in transcription
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    participating in Wnt signaling
    a component
  • a heterotetramer (2A, 2B) complexing with the FACT elongation transcription factor made of SSRP1 and FACTP140
  • two regulatory beta-subunits and two catalytic alpha- or alpha'-subunits
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • CKIP1
  • phosphorylating TP53 at Ser392 after UV irradiation
  • preferentially acidic proteins, broad specificity
  • RNPS1
  • is responsible for phosphorylation of SSB protein serine-366 and can modulate RPL37 5prime-terminal oligopyrimidine mRNA metabolism
  • interacts with the splicing factor PRPF3, which is important for the assembly of the spliceosome
  • interacting with beta-catenin
  • phosphorylating ARNTL
  • KIF5C is a new binding partner for CSNK2A2, CSNK2A1
  • PDX1 is a substrate for protein
  • its phosphorylation facilitates binding to the peptidyl-prolyl isomerase PIN1, which is required for CSNK2A1 mitotic spindle localization
  • CSNK2A1 did phosphorylate HSP90B1 even without the NLS-peptide, suggesting that an additional suppressive factor is required for NLS-dependent phosphorylation of HSP90B1 by CSNK2A1
  • interacting with CFTR (CSNK2A1 inhibition abolished CFTR conductance in cell-attached membrane patches, native epithelial ducts)
  • EEF1D is a CSNK2A1 substrate for CSNK2A1 phosphorylation
  • link between CSNK2A1 activity and IL6 expression
  • activation of SLC39A7 by CNSK2A1, a kinase that is antiapoptotic and promotes cell division, suggesting that SLC39A7 may provide a target for anticancer drug development
  • CSNK2A1 is the kinase responsible for phosphorylation PAX3 at Ser209, but also enables us to propose a mechanism describing the ordered and differential phosphorylation of PAX3 throughout early myogenesis
  • CSNK2A1 activity is inhibited by NOLC1 and reactivated by GPRIN2 by competitive binding at the substrate recognition site of CSNK2A1
  • CSNK2A1 is involved in the phosphorylation of the ESCRT-III subunits CHMP3 and CHMP2B, as well as of VPS4B/SKD1, an ATPase that mediates ESCRT-III disassembly
  • DNA-PKcs and ATM are stabilized by the TTT (TELO2, TTI1, TTI2) cochaperone family, whose actions are mediated by CSNK2A1 phosphorylation
  • CSNK2A1-dependent phosphorylation is a crucial event which, discriminating between AKT1 and AKT2, can account for different substrate specificities
  • CSNK2A1 interacts at the neuromuscular synapse with RAPSN, RAC1, YWHAG, and DOK7 proteins and phosphorylates the latter two
  • CSNK2A1, CSNK2A2-dependent phosphorylation of TOMM22 is a critical switch for mitophagy and reveal CSNK2A-dependent physiological implications on metabolism, muscle integrity and behavior
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    associated with hyperproliferation and suppression of apoptosis in cancer
    constitutional       loss of function
    resulted in an elevated level of insulin secretion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    selective CSNK2A1 inhibition or down-regulation in tumors may provide an attractive opportunity for the development of novel cancer therapies
    cancer  
    CSNK2A1 inhibitors, are potential therapies for multiple diseases that are driven by inflammation
    ANIMAL & CELL MODELS