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FLASH GENE
Symbol CSF2RB contributors: mct - updated : 22-03-2020
HGNC name colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
HGNC id 2436
Corresponding disease
CPAP2 congenital pulmonary alveolar proteinosis 2
Location 22q12.3      Physical location : 37.309.674 - 37.336.477
Synonym name
  • interleukin 3, interleukin 5 receptor common subunit beta (high affinity)
  • GM-CSF/IL-3/IL-5 receptor common beta-chain
  • CD131 antigen
  • interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity)
  • cytokine receptor common beta chain
  • Synonym symbol(s) GM-CSFRB, IL3RB, CD131, IL5RB, CDw131, SMDP5, betaGMR, betaCR
    DNA
    TYPE functioning gene
    STRUCTURE 26.88 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    APOL3 22q13.1 apolipoprotein L, 3 APOL4 22q13.1 apolipoprotein L, 4 APOL2 22q13.1 apolipoprotein L, 2 APOL1 22q13.1 apolipoprotein L, 1 MYH9 22q13.1 myosin, heavy polypeptide 9, non-muscle LOC388898 22 LOC388898 TXN2 22q13.1 thioredoxin 2 FLJ23322 22q13.1 hypothetical protein FLJ23322 EIF3S7 22q13.1 eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa CACNG2 22q13.1 calcium channel, voltage-dependent, gamma subunit 2 RABL4 22q13.1 RAB, member of RAS oncogene family-like 4 PVALB 22q13.1 parvalbumin NCF4 22q13.1 neutrophil cytosolic factor 4, 40kDa CSF2RB 22q13.1 colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) CSF2RB2 22q13.1 colony stimulating factor 2 receptor, beta, 2 MGC35206 22q13.1 hypothetical protein MGC35206 TST 22q13.1 thiosulfate sulfurtransferase (rhodanese) MPST 22q13.1 mercaptopyruvate sulfurtransferase FLJ12242 22q13.1 hypothetical protein FLJ12242 TMPRSS6 22q13.1 transmembrane serine protease 6 IL2RB 22q13.1 interleukin 2 receptor, beta C1QTNF6 22q13.1 C1q and tumor necrosis factor related protein 6 SSTR3 22q13.1 somatostatin receptor 3 RAC2 22q13.1 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) PSCD4 22q13.1 pleckstrin homology, Sec7 and coiled-coil domains 4 KIAA1904 22q13.1 KIAA1904 protein MFNG 22q13.1 manic fringe homolog (Drosophila) CARD10 22q13 caspase recruitment domain family, member 10 CDC42EP1 22q13.1 CDC42 effector protein (Rho GTPase binding) 1 LGALS2 22q13.1 lectin, galactoside-binding, soluble, 2 (galectin 2) GGA1 22q13.31 golgi associated, gamma adaptin ear containing, ARF binding protein 1 SH3BP1 22q13.1 SH3-domain binding protein 1 PLP
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 4853 - 897 - 2017 28131718
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Lymphoid/Immunelymph node   moderately
    Reproductivefemale systemplacenta  predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two fibronectin type-III domains
  • a box 1 motif required for JAK interaction and/or activation
  • a WSXWS motif necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Csf2rb2
    Homologene
    FAMILY
  • type I cytokine receptor family
  • type 4 subfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • type I membrane protein
  • basic FUNCTION
  • interleukin 3, interleukin 5 receptor common subunit beta (high affinity)
  • critical for the activation of both the JAK/STAT (JAK2, STAT5) and MAP kinase pathways
  • involved in LYN binding
  • plays an important role in preventing the ligand-receptor complexes from rapidly dissociating
  • plays a crucial role in EPO-mediated non-hematopoietic effects
  • may play an integrative role in the EPO signaling-mediated activation of endothelial NO synthase (eNOS) in endothelial cells (ECs)
  • may play an important role in the beneficial effects of EPO against OXLDL-elicited dysfunction of macrophage foam cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text antimicrobial humoral response
    PATHWAY
    metabolism
    signaling signal transduction
  • cytokine and chemokine mediated signaling pathway
  • a component
  • heterodimer of an alpha and a beta chain
  • the beta chain is common to the IL3, IL5 and GM-CSF receptors
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • engagement of IL-3 receptor beta common (IL-3R beta c) contributes to both IL-3- and VEGF-induced Rac1 activation, cell migration and in vitro tube-like structure formation as shown by the expression of the dominant-negative IL-3R beta c construct (Delta455)
  • NFKB1 activation by CSF2RB is dependent on TNFR-associated factor 6 (TRAF6) and association of TRAF6 with CSF2RB requires a consensus-binding motif found in other molecules known to interact with TRAF6
  • plays a crucial role in the nonhematopoietic effects of EPO (PMD: 26101463)
  • colocalized and interacted with EPO receptor (EPOR) in macrophages
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CPAP2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS