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FLASH GENE

Symbol

CSF2RB

contributors: mct - updated : 22-03-2020

HGNC name	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
HGNC id	2436

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CPAP2 congenital pulmonary alveolar proteinosis 2
Location	22q12.3      Physical location : 37.309.674 - 37.336.477
Synonym name	interleukin 3, interleukin 5 receptor common subunit beta (high affinity)
	GM-CSF/IL-3/IL-5 receptor common beta-chain
	CD131 antigen
	interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity)
	cytokine receptor common beta chain
Synonym symbol(s)	GM-CSFRB, IL3RB, CD131, IL5RB, CDw131, SMDP5, betaGMR, betaCR

DNA

TYPE	functioning gene
STRUCTURE	26.88 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000395 14 - 4853 NP_000386 - 897 - 2017 28131718

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       highly Lymphoid/Immune lymph node       moderately Reproductive female system placenta     predominantly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two fibronectin type-III domains
	a box 1 motif required for JAK interaction and/or activation
	a WSXWS motif necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding

conjugated

GlycoP

mono polymer

heteromer , dimer

HOMOLOGY

interspecies

ortholog to murine Csf2rb2

Homologene

FAMILY	type I cytokine receptor family
	type 4 subfamily

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I membrane protein

basic FUNCTION	interleukin 3, interleukin 5 receptor common subunit beta (high affinity)
	critical for the activation of both the JAK/STAT (JAK2, STAT5) and MAP kinase pathways
	involved in LYN binding
	plays an important role in preventing the ligand-receptor complexes from rapidly dissociating
	plays a crucial role in EPO-mediated non-hematopoietic effects
	may play an integrative role in the EPO signaling-mediated activation of endothelial NO synthase (eNOS) in endothelial cells (ECs)
	may play an important role in the beneficial effects of EPO against OXLDL-elicited dysfunction of macrophage foam cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

text	antimicrobial humoral response

PATHWAY

metabolism

signaling

signal transduction

cytokine and chemokine mediated signaling pathway

a component	heterodimer of an alpha and a beta chain
	the beta chain is common to the IL3, IL5 and GM-CSF receptors

INTERACTION

DNA

RNA

small molecule

protein	engagement of IL-3 receptor beta common (IL-3R beta c) contributes to both IL-3- and VEGF-induced Rac1 activation, cell migration and in vitro tube-like structure formation as shown by the expression of the dominant-negative IL-3R beta c construct (Delta455)
	NFKB1 activation by CSF2RB is dependent on TNFR-associated factor 6 (TRAF6) and association of TRAF6 with CSF2RB requires a consensus-binding motif found in other molecules known to interact with TRAF6
	plays a crucial role in the nonhematopoietic effects of EPO (PMD: 26101463)
	colocalized and interacted with EPO receptor (EPOR) in macrophages

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CPAP2

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS