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FLASH GENE
Symbol CSF2RB contributors: mct - updated : 22-03-2020
HGNC name colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
HGNC id 2436
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 4853 - 897 - 2017 28131718
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly
Lymphoid/Immunelymph node   moderately
Reproductivefemale systemplacenta  predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion blood
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two fibronectin type-III domains
  • a box 1 motif required for JAK interaction and/or activation
  • a WSXWS motif necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Csf2rb2
    Homologene
    FAMILY
  • type I cytokine receptor family
  • type 4 subfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • type I membrane protein
  • basic FUNCTION
  • interleukin 3, interleukin 5 receptor common subunit beta (high affinity)
  • critical for the activation of both the JAK/STAT (JAK2, STAT5) and MAP kinase pathways
  • involved in LYN binding
  • plays an important role in preventing the ligand-receptor complexes from rapidly dissociating
  • plays a crucial role in EPO-mediated non-hematopoietic effects
  • may play an integrative role in the EPO signaling-mediated activation of endothelial NO synthase (eNOS) in endothelial cells (ECs)
  • may play an important role in the beneficial effects of EPO against OXLDL-elicited dysfunction of macrophage foam cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text antimicrobial humoral response
    PATHWAY
    metabolism
    signaling signal transduction
  • cytokine and chemokine mediated signaling pathway
  • a component
  • heterodimer of an alpha and a beta chain
  • the beta chain is common to the IL3, IL5 and GM-CSF receptors
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • engagement of IL-3 receptor beta common (IL-3R beta c) contributes to both IL-3- and VEGF-induced Rac1 activation, cell migration and in vitro tube-like structure formation as shown by the expression of the dominant-negative IL-3R beta c construct (Delta455)
  • NFKB1 activation by CSF2RB is dependent on TNFR-associated factor 6 (TRAF6) and association of TRAF6 with CSF2RB requires a consensus-binding motif found in other molecules known to interact with TRAF6
  • plays a crucial role in the nonhematopoietic effects of EPO (PMD: 26101463)
  • colocalized and interacted with EPO receptor (EPOR) in macrophages
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CPAP2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS