| morpholino knockdown of crim1 showed some evidence of ventralisation, including expansion of the intermediate cell mass , reduction in head size bent tails and disruption to the somites and notochord | |
Crim1(KST264/KST264) mice displayed perinatal lethality, syndactyly, eye, and kidney abnormalities |
|
Crim1(KST264/KST264) mice displayed abnormal glomerular development, illustrated by enlarged capillary loops, podocyte effacement, and mesangiolysis |
|
Deficiency of Crm1 provoked by RNAi decreased the spindle poles localization of pericentrin and gamma-tubulin complex, coupled with mitotic defects |
|
adult Crim1(KST264/KST264) mice display renal vascular defects extend to the peritubular microvasculature with abnormal endothelium and collagen deposition between the endothelium and the tubular basement membrane |
|
Crim1(KST264/KST264) mutant placentae displayed hypoplasia from 13.5 dpc, and altered structure from 15.5 dpc, including alterations in cell number in both the junctional and labyrinth zones |
|
In the frog Xenopus laevis, loss of function studies using CRIM1 antisense morpholino oligonucleotides resulted in a failure of neural development |
|
Crim1(KST264/KST264) mice present with hydronephrosis, suggesting obstructive nephropathy |