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Symbol CRIM1 contributors: npt/shn - updated : 02-05-2013
HGNC name cysteine rich transmembrane BMP regulator 1 (chordin-like)
HGNC id 2359
corresponding disease(s)
Variant & Polymorphism
Candidate gene
Therapy target
  • morpholino knockdown of crim1 showed some evidence of ventralisation, including expansion of the intermediate cell mass , reduction in head size bent tails and disruption to the somites and notochord
  • Crim1(KST264/KST264) mice displayed perinatal lethality, syndactyly, eye, and kidney abnormalities
  • Crim1(KST264/KST264) mice displayed abnormal glomerular development, illustrated by enlarged capillary loops, podocyte effacement, and mesangiolysis
  • Deficiency of Crm1 provoked by RNAi decreased the spindle poles localization of pericentrin and gamma-tubulin complex, coupled with mitotic defects
  • adult Crim1(KST264/KST264) mice display renal vascular defects extend to the peritubular microvasculature with abnormal endothelium and collagen deposition between the endothelium and the tubular basement membrane
  • Crim1(KST264/KST264) mutant placentae displayed hypoplasia from 13.5 dpc, and altered structure from 15.5 dpc, including alterations in cell number in both the junctional and labyrinth zones
  • In the frog Xenopus laevis, loss of function studies using CRIM1 antisense morpholino oligonucleotides resulted in a failure of neural development
  • Crim1(KST264/KST264) mice present with hydronephrosis, suggesting obstructive nephropathy