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FLASH GENE

Symbol

CREBL2

contributors: npt/mct - updated : 20/11/2008

HGNC name	cAMP responsive element binding protein-like 2
HGNC id	2350

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12p13.2-p13.1      Physical location : 12.764.830 - 12.798.041
Synonym symbol(s)	MGC117311, MGC138362

DNA

TYPE	like-sequence
STRUCTURE	33.21 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

motif

MAPPING

cloned

Y

linked

status

provisional

Map	pter - ETV6 - D12S358 - CREBL2 - CDKN1B - cen
Authors	Hoornaert (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CREBL2 4 - 3748 13 120 - Hoornaert (1998)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Endocrine adrenal gland       highly   neuroendocrine pituitary     highly Hearing/Equilibrium ear       highly Reproductive male system testis     highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		fibrous
STRUCTURE

motifs/domains	a basic leucine-zipper (bZIP) domain
	a DNA binding domain, rich in basic residues
	a leucine zipper involved in protein dimerization

HOMOLOGY

Homologene

FAMILY	bZIP family
	ATF subfamily

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

acting as a suppressor of tumor

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS