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FLASH GENE
Symbol CREB3L3 contributors: mct/npt/pgu - updated : 27-11-2016
HGNC name cAMP responsive element binding protein 3-like 3
HGNC id 18855
Location 19p13.3      Physical location : 4.153.628 - 4.173.047
Synonym name
  • CREB/ATF family transcription factor
  • transcription factor CREB-H
    • Synonym symbol(s) CREB-H, HYST1481, MGC126553, MGC126557, CREBH
    DNA
    TYPE functioning gene
    STRUCTURE 19.42 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2586 - 461 - 2009 19679815
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine    Homo sapiens
     liver     Homo sapiens
     stomach    
    Reproductivefemale systembreastmammary gland  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a bZip domain
  • a predicted transmembrane domain
  • an adjacent cleavage site for the Golgi protease S1P, with conserved features which indicate that it represents a specific subclass of S1P sites
    • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • CREB/ATF family
  • bZIP family
  • ATF subfamily
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text under normal conditions transported back from the ER to the cytosol, where it is subject to ERAD, but under conditions that repress proteasome function or promote load CREB3L3 is diverted from this pathway instead undergoing cleavage and nuclear transport
    basic FUNCTION
  • acting during endoplasmic reticulum stress by activating unfolded protein response target genes
  • playing an important role in transcriptional regulation
    • of genes specifically expressed in the liver
  • ATF6-related, transmembrane transcription factor that, in response to endoplasmic reticulum (ER)-associated stress, is cleaved by Golgi proteases and transported to the nucleus to effect appropriate adaptive responses
  • required for hepcidin promoter activity
  • activates the expression of classic acute-phase response genes, such as CRP and hepcidin, a peptide that also qualifies as a main acute-phase response gene )
  • required for the maintenance of normal plasma triglyceride concentrations, and crucial role in human triglyceride metabolism
  • functions as a key metabolic regulator that controls glucose homeostasis across the circadian cycle or under metabolic stress
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • new intracellular signaling pathway that controls ubiquitination and degradation of the active form of CREB3L3transcription factor
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to and transactivates the hepcidin promoter )
  • directly controls APOA4 expression through two tandem CREBH binding sites (5'-CCACGTTG-3') located on the promoter, which are conserved
  • is the major transcription factor regulating APOA4 gene expression
  • BTRC-mediated ubiquitination and degradation of liver-enriched transcription factor CREB3L3
  • CREB3L3 regulates the rhythmic expression of the genes encoding the rate-limiting enzymes for glycogenolysis and gluconeogenesis, including PYGL, PCK1, and G6PC
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS