basic FUNCTION
| acting during endoplasmic reticulum stress by activating unfolded protein response target genes |
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playing an important role in transcriptional regulation |
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of genes specifically expressed in the liver |
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ATF6-related, transmembrane transcription factor that, in response to endoplasmic reticulum (ER)-associated stress, is cleaved by Golgi proteases and transported to the nucleus to effect appropriate adaptive responses |
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required for hepcidin promoter activity |
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activates the expression of classic acute-phase response genes, such as CRP and hepcidin, a peptide that also qualifies as a main acute-phase response gene ) |
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required for the maintenance of normal plasma triglyceride concentrations, and crucial role in human triglyceride metabolism |
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functions as a key metabolic regulator that controls glucose homeostasis across the circadian cycle or under metabolic stress |