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FLASH GENE
Symbol CNTROB contributors: mct/pgu - updated : 20-05-2015
HGNC name centrobin, centrosomal BRCA2 interacting protein
HGNC id 29616
Location 17p13.1      Physical location : 7.835.472 - 7.852.895
Synonym name
  • LYST-interacting protein 8
  • centrobin
    • Synonym symbol(s) LIP8, PP1221, NIP2
    DNA
    TYPE functioning gene
    STRUCTURE 17.42 kb     20 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 3803 103.7 925 - 2007 17535851
    19 - 3737 101.12 903 - 2007 17535851
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils    
    Nervousnerve    
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • daughter-centriole-specific, but also found in association with a stable microtubule network of cytoplasm
  • recruited to the centriole biogenesis site via its interaction with tubulins during the early stage of centriole biogenesis
    • basic FUNCTION
  • has a role in stabilizing the microtubule structure (its phosphorylation may be crucial for mobilization of the protein to a new microtubule and stabilizing it)
  • plays an important role in the progression of cell cycle, and a tight association between the cell-cycle progression and defective centrosomes caused by depletion of centrobin
  • centrosomal protein that is required for centrosome duplication
  • critical for microtubule organization in both interphase and mitotic cells
  • centrosome protein required for centriole duplication
  • functions as a microtubule stabilizing factor
  • is required in maintaining centrosome integrity, which in turn promotes anchoring of mitotic spindle to the centrosomes
  • daughter centriole protein that is essential for centrosome duplication
  • facilitates the elongation and stability of centrioles via its interaction with tubulins
  • centrosome protein for centriole duplication, and also involved in other cellular functions, such as spindle assembly
  • might regulate microtubule nucleation and organization by controlling the amount of pericentriolar matrix
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • substrate of NEK2 and its centrosomal localization is controlled by NEK2
  • also a substrate of PLK1
  • interacts with tubulin directly, and centrobin-tubulin interaction is pivotal for the function of centrobin during centriole duplication
  • CNTROB is a substrate of both NEK2 and PLK1 (NEK2 phosphorylation antagonizes the microtubule stabilizing activity of CNTROB)
  • CNTROB-CENPJ interaction is critical for the recruitment of CENPJ to procentrioles to promote the elongation of daughter centrioles and for the persistence of CENPJ on preexisting mother centrioles
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene may represent a novel candidate gene for presently unexplained hereditary forms of teratozoospermia and the "easily decapitated sperm syndrome"
    Marker
    Therapy target
    ANIMAL & CELL MODELS