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FLASH GENE
Symbol CNTROB contributors: mct/pgu - updated : 20-05-2015
HGNC name centrobin, centrosomal BRCA2 interacting protein
HGNC id 29616
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
text
  • daughter-centriole-specific, but also found in association with a stable microtubule network of cytoplasm
  • recruited to the centriole biogenesis site via its interaction with tubulins during the early stage of centriole biogenesis
  • basic FUNCTION
  • has a role in stabilizing the microtubule structure (its phosphorylation may be crucial for mobilization of the protein to a new microtubule and stabilizing it)
  • plays an important role in the progression of cell cycle, and a tight association between the cell-cycle progression and defective centrosomes caused by depletion of centrobin
  • centrosomal protein that is required for centrosome duplication
  • critical for microtubule organization in both interphase and mitotic cells
  • centrosome protein required for centriole duplication
  • functions as a microtubule stabilizing factor
  • is required in maintaining centrosome integrity, which in turn promotes anchoring of mitotic spindle to the centrosomes
  • daughter centriole protein that is essential for centrosome duplication
  • facilitates the elongation and stability of centrioles via its interaction with tubulins
  • centrosome protein for centriole duplication, and also involved in other cellular functions, such as spindle assembly
  • might regulate microtubule nucleation and organization by controlling the amount of pericentriolar matrix
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • substrate of NEK2 and its centrosomal localization is controlled by NEK2
  • also a substrate of PLK1
  • interacts with tubulin directly, and centrobin-tubulin interaction is pivotal for the function of centrobin during centriole duplication
  • CNTROB is a substrate of both NEK2 and PLK1 (NEK2 phosphorylation antagonizes the microtubule stabilizing activity of CNTROB)
  • CNTROB-CENPJ interaction is critical for the recruitment of CENPJ to procentrioles to promote the elongation of daughter centrioles and for the persistence of CENPJ on preexisting mother centrioles
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene may represent a novel candidate gene for presently unexplained hereditary forms of teratozoospermia and the "easily decapitated sperm syndrome"
    Marker
    Therapy target
    ANIMAL & CELL MODELS