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FLASH GENE
Symbol CNNM2 contributors: mct - updated : 15-10-2018
HGNC name cyclin M2
HGNC id 103
Corresponding disease
HOMGSMR1 hypomagnesemia, seizures, and mental retardation 1
Location 10q24.32      Physical location : 104.678.113 - 104.838.238
Synonym name
  • ancient conserved domain protein 2
  • metal transporter CNNM2
  • Synonym symbol(s) ACDP2
    DNA
    TYPE functioning gene
    STRUCTURE 160.13 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 4071 - 875 brain, kidney, placenta (highly), skeletal muscle (weakly), lung, spleen, testis 2012 22399287
  • isoform 1, CNNM2a
  • both CNNM2a and CNNM2b can form homomultimers as well as heteromultimers
  • 7 - 4005 - 853 kidney, brain, spleen, testis 2012 22399287
  • isoform 2
  • 22-AAs-shorter isoform b is translated from splice variant 2 (Cnnm2v2), which lacks exon 6
  • both CNNM2a and CNNM2b can form homomultimers as well as heteromultimers
  • 2 - 2037 - 552 - 2012 22399287
  • isoform 3
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly Homo sapiens
    Nervousbrain   moderately Homo sapiens
    Reproductivemale systemtestis  highly Homo sapiens
    Urinarykidneynephron  predominantly Homo sapiens
     kidneytubuleconvoluted tubuledistal tubulepredominantly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinarytubular cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a long N-terminal signal peptide of 64 amino acids, that is cleaved in the ER
  • extracellular N terminus
  • two conserved CBS forming a stable globular domain, conserved cystathionine-&
  • 946;-synthase (CBS) domains and with unique binding ability to ATP
  • five potential transmembrane (TM) domains
  • an intracellular C terminus
  • HOMOLOGY
    interspecies homolog to murine Cnnm2 (98.3pc)
    homolog to rattus Cnnm2 (97.7pc)
    Homologene
    FAMILY
  • ACDP family, CNNM family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text reside at the plasma membrane
    basic FUNCTION
  • may be involved in transport of ions Mg2+, Co2+, Mn2+, Sr2+, Ba2+, Cu2+, Fe2+
  • having a role in the cell cycle
  • would likely sense intracellular Mg2+ concentrations and regulate other Mg2+ transporters
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text ion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARL15 also inhibits CNNM2 Mg2+ efflux
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HOMGSMR1
    Susceptibility
    Variant & Polymorphism SNP
  • SNP is associated with blood pressure and/or hypertension in the Japanese (Takeuchi 2010)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS