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FLASH GENE
Symbol CNNM2 contributors: mct - updated : 15-10-2018
HGNC name cyclin M2
HGNC id 103
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a long N-terminal signal peptide of 64 amino acids, that is cleaved in the ER
  • extracellular N terminus
  • two conserved CBS forming a stable globular domain, conserved cystathionine-&
    • 946;-synthase (CBS) domains and with unique binding ability to ATP
  • five potential transmembrane (TM) domains
  • an intracellular C terminus
    • HOMOLOGY
    interspecies homolog to murine Cnnm2 (98.3pc)
    homolog to rattus Cnnm2 (97.7pc)
    Homologene
    FAMILY
  • ACDP family, CNNM family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text reside at the plasma membrane
    basic FUNCTION
  • may be involved in transport of ions Mg2+, Co2+, Mn2+, Sr2+, Ba2+, Cu2+, Fe2+
  • having a role in the cell cycle
  • would likely sense intracellular Mg2+ concentrations and regulate other Mg2+ transporters
    • CELLULAR PROCESS cell cycle, division, mitosis
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text ion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARL15 also inhibits CNNM2 Mg2+ efflux
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HOMGSMR1
    Susceptibility
    Variant & Polymorphism SNP
  • SNP is associated with blood pressure and/or hypertension in the Japanese (Takeuchi 2010)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS