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FLASH GENE

Symbol

CMA1

contributors: mct - updated : 12-03-2007

HGNC name	chymase 1, mast cell
HGNC id	2097

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q11.2      Physical location : 24.974.711 - 24.977.471
Synonym name	mast cell protease I
Synonym symbol(s)	CHYM, MCT1, MGC119890, MGC119891
EC.number	3.4.21.39

DNA

TYPE	functioning gene
STRUCTURE	2.00 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - TRA@ /TRD@ - GZMB - GZMH - CTSG - CMA1 - qter
Authors	Caughey (93)

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Respiratory lung         Skin/Tegument skin

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic

cells

System Cell Pubmed Species Stage Rna symbol   mast cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Cma1

Homologene

FAMILY	trypsin family
	granzyme subfamily
	peptidase family S1

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,granule

basic FUNCTION	serine protease, cleaving chymotrypsin
	degradation of the extracellular matrix, regulation of submucosal gland secretion, and generation of vasoactive peptides
	largely responsible in the heart and blood vessels, for converting angiotensin I to the vasoactive peptide angiotensin II
	activated human skin mast cells (MCs) convert CTAP-III into biologically active NAP-2 through proteolytic cleavage by released chymase

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

digestion

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	chymotrypsin
	Human mast cell chymase caused conjunctival epithelial cell detachment by degrading fibronectin, and this led to secondary apoptosis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to atopy

Variant & Polymorphism	a variant putatively involved in eczema

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS