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FLASH GENE
Symbol CMA1 contributors: mct - updated : 12-03-2007
HGNC name chymase 1, mast cell
HGNC id 2097
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Respiratorylung    
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
 mast cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Cma1
Homologene
FAMILY
  • trypsin family
  • granzyme subfamily
  • peptidase family S1
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • serine protease, cleaving chymotrypsin
  • degradation of the extracellular matrix, regulation of submucosal gland secretion, and generation of vasoactive peptides
  • largely responsible in the heart and blood vessels, for converting angiotensin I to the vasoactive peptide angiotensin II
  • activated human skin mast cells (MCs) convert CTAP-III into biologically active NAP-2 through proteolytic cleavage by released chymase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • chymotrypsin
  • Human mast cell chymase caused conjunctival epithelial cell detachment by degrading fibronectin, and this led to secondary apoptosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to atopy
    Variant & Polymorphism a variant putatively involved in eczema
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS