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FLASH GENE
Symbol CLIC1 contributors: mct/pgu - updated : 05-11-2013
HGNC name chloride intracellular channel 1
HGNC id 2062
Location 6p21.33      Physical location : 2.983.926 - 31.704.341
Synonym name
  • chloride channel ABP
  • nuclear chloride ion channel 27
  • regulatory nuclear chloride ion channel protein
  • Synonym symbol(s) G6, NCC27, p64CLCP
    DNA
    TYPE functioning gene
    STRUCTURE 6.74 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    BAT1 6p21.33 HLA-B associated transcript 1 ATP6V1G2 6p21.3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 2 NFKBIL1 6p21.3 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 LTA 6p21.3 lymphotoxin alpha (TNF superfamily, member 1) TNF 6p21.3 tumor necrosis factor (TNF superfamily, member 2) LTB 6p21.3 lymphotoxin beta (TNF superfamily, member 3) LST1 6p21.3 leukocyte specific transcript 1 NCR3 6p21.3 natural cytotoxicity triggering receptor 3 AIF1 6p21.3 allograft inflammatory factor 1 BAT2 6p21.33 HLA-B associated transcript 2 BAT3 6p21.33 HLA-B associated transcript 3 APOM 6p21.31 apolipoprotein M C6orf47 6p21.3 chromosome 6 open reading frame 47 BAT4 6p21.33 HLA-B associated transcript 4 CSNK2B 6p21.3 casein kinase 2, beta polypeptide LY6G5B 6p21.3 lymphocyte antigen 6 complex, locus G5B LY6G5C 6p21.3 lymphocyte antigen 6 complex, locus G5C BAT5 6p21.33 HLA-B associated transcript 5 LY6G6D 6p21.3 lymphocyte antigen 6 complex, locus G6D LY6G6E 6p21.3 lymphocyte antigen 6 complex, locus G6E LY6G6C 6p21.3 lymphocyte antigen 6 complex, locus G6C C6orf25 6p21.3 chromosome 6 open reading frame 25 DDAH2 6p21.3 dimethylarginine dimethylaminohydrolase 2 CLIC1 6p21.3 chloride intracellular channel 1 MSH5 6p21.3 mutS homolog 5 (E. coli) C6orf27 6p21.31 chromosome 6 open reading frame 27 VARS2 6p21.3 valyl-tRNA synthetase 2 LSM2 6p21.3 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) HSPA1L 6p21.3 heat shock 70kDa protein 1-like HSPA1A 6p21.3 heat shock 70kDa protein 1A HSPA1B 6p21.3 heat shock 70kDa protein 1B C6orf48 6p21.3 chromosome 6 open reading frame 48 NEU1 6p21.3 sialidase 1 (lysosomal sialidase) C6orf29 6p21.3 chromosome 6 open reading frame 29 BAT8 6p21.31 HLA-B associated transcript 8 C6orf46 6p21.31 chromosome 6 open reading frame 46 C2 6p21.3 complement component 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1265 - 241 - 2010 : 200857
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivepharynx   highly
     stomach   highly
    Respiratorylung   highly
    Urinarykidneynephron   
    Visualeyeanterior segmentcornea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Muscularsmooth   
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain of CLIC1 is likely to insert into the lipid bilayer
  • C-domain remaining in solution on the extravesicular side of the membrane
  • mono polymer homomer , monomer , dimer
    HOMOLOGY
    interspecies homolog to murine Clic1
    Homologene
    FAMILY
  • glutathione S transferase fold family
  • CLIC family of chloride channels
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    intracellular,nuclear envelope
    text
  • nuclear membrane brush border of renal PCT
  • following microglial activation, CLIC1 translocates from cytosol to plasma membrane where it promotes a chloride conductance
  • basic FUNCTION
  • chloride voltage-gated channel regulatory protein
  • regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume
  • exhibits both nuclear and plasma membrane chloride ion channel activity
  • actin-regulated membrane protein that could modify solute transport at key stages during cellular events such as apoptosis, cell and organelle division and fusion, cell-volume regulation, and cell movement
  • may play a role in the regulation of osteoblastic differentiation from mesenchymal progenitors
  • acting as both a second messenger and an executor during oxidative stress
  • forms oligomers upon oxidation in the presence of the membranes
  • involved in the lymphatic metastasis of tumors
  • important role for CLIC1 in regulating macrophage function through its ion channel activity, suggesting it is a suitable target for the development of anti-inflammatory drug
  • having the ability to spontaneously insert into lipid membranes from a soluble, globular state
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TRAPPC2
  • cell & other
    REGULATION
    inhibited by strongly and reversibly inhibited (or inactivated) by cytosolic F-actin in the absence of any other protein
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    potential target and prognostic biomarker
    ANIMAL & CELL MODELS
  • Clic1(-/-) murine macrophages displayed impaired phagosomal proteolytic capacity and reduced reactive oxygen species production