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FLASH GENE
Symbol CLIC1 contributors: mct/pgu - updated : 05-11-2013
HGNC name chloride intracellular channel 1
HGNC id 2062
DNA
TYPE functioning gene
STRUCTURE 6.74 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1265 - 241 - 2010 : 200857
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivepharynx   highly
 stomach   highly
Respiratorylung   highly
Urinarykidneynephron   
Visualeyeanterior segmentcornea  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Muscularsmooth   
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain of CLIC1 is likely to insert into the lipid bilayer
  • C-domain remaining in solution on the extravesicular side of the membrane
  • mono polymer homomer , monomer , dimer
    HOMOLOGY
    interspecies homolog to murine Clic1
    Homologene
    FAMILY
  • glutathione S transferase fold family
  • CLIC family of chloride channels
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    intracellular,nuclear envelope
    text
  • nuclear membrane brush border of renal PCT
  • following microglial activation, CLIC1 translocates from cytosol to plasma membrane where it promotes a chloride conductance
  • basic FUNCTION
  • chloride voltage-gated channel regulatory protein
  • regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume
  • exhibits both nuclear and plasma membrane chloride ion channel activity
  • actin-regulated membrane protein that could modify solute transport at key stages during cellular events such as apoptosis, cell and organelle division and fusion, cell-volume regulation, and cell movement
  • may play a role in the regulation of osteoblastic differentiation from mesenchymal progenitors
  • acting as both a second messenger and an executor during oxidative stress
  • forms oligomers upon oxidation in the presence of the membranes
  • involved in the lymphatic metastasis of tumors
  • important role for CLIC1 in regulating macrophage function through its ion channel activity, suggesting it is a suitable target for the development of anti-inflammatory drug
  • having the ability to spontaneously insert into lipid membranes from a soluble, globular state
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TRAPPC2
  • cell & other
    REGULATION
    inhibited by strongly and reversibly inhibited (or inactivated) by cytosolic F-actin in the absence of any other protein
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    potential target and prognostic biomarker
    ANIMAL & CELL MODELS
  • Clic1(-/-) murine macrophages displayed impaired phagosomal proteolytic capacity and reduced reactive oxygen species production