C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12
Synonym symbol(s)
BGR, DECTIN1, CLECSF12
DNA
TYPE
functioning gene
STRUCTURE
13.49 kb 6 Exon(s)
MAPPING
cloned
Y
linked
Y
status
provisional
regionally located
. being closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region
. located between OLR1 and CD94
RNA
TRANSCRIPTS
type
messenger
identification
nb exons
type
bp
product
Protein
kDa
AA
specific expression
Year
Pubmed
6
splicing
2622
27
247
-
Yokota, Willment, Hermanz-Falcon (2001)
isoform a
5
splicing
2484
22
201
-
Yokota, Willment, Hermanz-Falcon (2001)
lacking an in-frame segment of the coding region compared to variant 1
lacking a stalk domain compared to variant 1
isoform b
5
splicing
2503
20.9
189
-
Willment, Hermanz-Falcon (2001)
lacking a segment of the coding region, which leads to a frameshift and an early sto codon, compared to variant 1
isoform c
4
splicing
2365
16
143
-
Willment, (Hermanz-Falcón 2001)
lacking two segments of the coding region, leading to a frameshift and an early stop codon, compared to variant 1
isoform d
4
splicing
2385
19
168
-
Willment, Hermanz-Falcon (2001), Xie (2006)
lacking an in-frame exon compared to variant 1
isoform e Dectin 1E
having a complete C-type lectin-like domain as well as an ITAM-like sequence
mainly resided in the cytoplasm
interacting with RANBP9 (the region containing SPRY domain was sufficient for the interaction)
3
splicing
519
8.2
77
-
Willment, Hermanz-Falcon (2001)
multiple differences in the coding region, one of which resulting in an early stop codon
isoform f
EXPRESSION
Type
restricted
expressed in
(based on citations)
organ(s)
System
Organ level 1
Organ level 2
Organ level 3
Organ level 4
Level
Pubmed
Species
Stage
Rna symbol
Cardiovascular
vessel
highly
Respiratory
respiratory tract
larynx
highly
Urinary
bladder
moderately
tissue
System
Tissue
Tissue level 1
Tissue level 2
Level
Pubmed
Species
Stage
Rna symbol
Blood / hematopoietic
bone marrow
Epithelial
barrier lining
epidermis
cells
System
Cell
Pubmed
Species
Stage
Rna symbol
Blood/Hematopoietic
epidermal dendritic cell
Blood/Hematopoietic
leukocyte
Blood/Hematopoietic
monocyte
Lymphoid/Immune
macrophage
cell lineage
cell lines
fluid/secretion
blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
an extracellular C-type lectin-like domain fold
a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif
primary monocytes and macrophages express CLEC7A on the cell membrane (Ferwerda 2008)
basic FUNCTION
may act as a pattern recognition receptor for beta-glucan from fungi and plants, so playing a role in innate immune response
C-type lectin-like receptor gene expressed on dendritic cells (Hermanz-Falcón 2001)
may play a role in inflammation
involved in the uptake and cross-presentation of cellular antigens (Weck 2008)
synergizes with TLR2 and TLR4 for cytokine production in primary monocytes and macrophages (Ferwerda 2008)
key receptor influencing critical biological functions of dendritic cells in response to C. albicans leading to T cells response alteration (largely, though not completely, mediated by Syk activation) (Skrzypek 2009)
can induce its own intracellular signalling and can mediate a variety of cellular responses, such as cytokine production (Reid 2009)
involved in anti-fungal immunity, and in the control of mycobacterial infections (Reid 2009)
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
immunity/defense
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
interacting with SH3GL1 (involves the mechanism of action of CLEC7A on phagocytosis in macrophages)
its phosphatase function positively regulates CLEC7A- and TDGF1P3-stimulated ROS production in macrophages by dephosphorylating and thus mitigating the inhibitory function of SIRPA and by promoting Erk activation
cell & other
REGULATION
Other
regulated by CD37 (CD37 is important for CLEC7A stabilization in APC membranes and controls CLEC7A-mediated IL6 production (Meyer-Wentrup 2007)