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FLASH GENE
Symbol CLEC7A contributors: mct/npt - updated : 16-12-2009
HGNC name C-type lectin domain family 7, member A
HGNC id 14558
DNA
TYPE functioning gene
STRUCTURE 13.49 kb     6 Exon(s)
MAPPING cloned Y linked Y status provisional
regionally located . being closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region . located between OLR1 and CD94
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 splicing 2622 27 247 - Yokota, Willment, Hermanz-Falcon (2001)
isoform a
5 splicing 2484 22 201 - Yokota, Willment, Hermanz-Falcon (2001)
  • lacking an in-frame segment of the coding region compared to variant 1
  • lacking a stalk domain compared to variant 1
  • isoform b
  • 5 splicing 2503 20.9 189 - Willment, Hermanz-Falcon (2001)
  • lacking a segment of the coding region, which leads to a frameshift and an early sto codon, compared to variant 1
  • isoform c
  • 4 splicing 2365 16 143 - Willment, (Hermanz-Falcón 2001)
  • lacking two segments of the coding region, leading to a frameshift and an early stop codon, compared to variant 1
  • isoform d
  • 4 splicing 2385 19 168 - Willment, Hermanz-Falcon (2001), Xie (2006)
  • lacking an in-frame exon compared to variant 1
  • isoform e Dectin 1E
  • having a complete C-type lectin-like domain as well as an ITAM-like sequence
  • mainly resided in the cytoplasm
  • interacting with RANBP9 (the region containing SPRY domain was sufficient for the interaction)
  • 3 splicing 519 8.2 77 - Willment, Hermanz-Falcon (2001)
  • multiple differences in the coding region, one of which resulting in an early stop codon
  • isoform f
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Respiratoryrespiratory tractlarynx  highly
    Urinarybladder   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Epithelialbarrier liningepidermis  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticepidermal dendritic cell
    Blood/Hematopoieticleukocyte
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an extracellular C-type lectin-like domain fold
  • a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif
  • a stalk domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Clec7a
    Homologene
    FAMILY
  • C-type lectin family
  • C-type lectin-like domain (CTL/CTLD) superfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION
    text
  • type II transmembrane protein
  • primary monocytes and macrophages express CLEC7A on the cell membrane (Ferwerda 2008)
  • basic FUNCTION
  • may act as a pattern recognition receptor for beta-glucan from fungi and plants, so playing a role in innate immune response
  • C-type lectin-like receptor gene expressed on dendritic cells (Hermanz-Falcón 2001)
  • may play a role in inflammation
  • involved in the uptake and cross-presentation of cellular antigens (Weck 2008)
  • synergizes with TLR2 and TLR4 for cytokine production in primary monocytes and macrophages (Ferwerda 2008)
  • key receptor influencing critical biological functions of dendritic cells in response to C. albicans leading to T cells response alteration (largely, though not completely, mediated by Syk activation) (Skrzypek 2009)
  • can induce its own intracellular signalling and can mediate a variety of cellular responses, such as cytokine production (Reid 2009)
  • involved in anti-fungal immunity, and in the control of mycobacterial infections (Reid 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with SH3GL1 (involves the mechanism of action of CLEC7A on phagocytosis in macrophages)
  • its phosphatase function positively regulates CLEC7A- and TDGF1P3-stimulated ROS production in macrophages by dephosphorylating and thus mitigating the inhibitory function of SIRPA and by promoting Erk activation
  • cell & other
    REGULATION
    Other regulated by CD37 (CD37 is important for CLEC7A stabilization in APC membranes and controls CLEC7A-mediated IL6 production (Meyer-Wentrup 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s) CANDF4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS