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FLASH GENE
Symbol CLCN4 contributors: - updated : 02-09-2005
HGNC name chloride channel 4
HGNC id 2022
Location Xp22.31      Physical location : 10.124.984 - 10.205.697
Synonym symbol(s) CLC-4, CLC4
DNA
TYPE functioning gene
STRUCTURE 78.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
regionally located close to APXL and OA1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve alpha helical membrane spanning domains
  • cytoplasmic, N and C terminal domains
  • HOMOLOGY
    interspecies ortholog to rattus Clcn4-2
    Homologene
    FAMILY chloride channel family
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • chloride voltage-gated channel activity
  • functioning as electrogenic exchanger, carrying a substantial amount of protons across the plasma membrane when activated by positive voltages
  • contributing to endosomal acidification and trafficking
  • stimulating copper incorporation into ceruloplasmin
  • may contribute to the pathogenesis of neuronal disorders
  • may compensate the charge accumulation by endosomal proton pumps
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by positive voltages
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS