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FLASH GENE

Symbol

CLCF1

contributors: mct - updated : 10-04-2007

HGNC name	cardiotrophin-like cytokine factor 1
HGNC id	17412

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CISS2 cold-induced sweating syndrome 2
Location	11q13      Physical location : 67.131.640 - 67.141.648
Synonym name	cardiotrophin-like cytokine
	neutrophin-1/B cell stimulating factor 3
	B cell-stimulating factor 3
	novel neurotrophin-1
Synonym symbol(s)	NNT1, CLC, BSF3, NR6

DNA

TYPE	functioning gene
STRUCTURE	9.00 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Lymphoid/Immune lymph node       predominantly   spleen       predominantly Nervous brain

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a conserved binding site on ciliary neurotrophic factor receptor (CNTFR)

secondary structure

alpha helices

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine Bsf3
	ortholog to murine Clcf1
	ortholog to rattus Clc

intraspecies

paralog to CNTF

Homologene

FAMILY

interleukin-6 cytokine family member

CATEGORY

signaling cytokine

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	cytokine with B cell stimulating activity
	activating IL6ST receptor, LIFR and signal transducer and activator of transcription 3 (STAT3)
	second ligand for CNTFR
	share a conserved binding site on ciliary neurotrophic factor receptor (CNTFR)

CELLULAR PROCESS	cell life, cell death/apoptosis
	cell communication

PHYSIOLOGICAL PROCESS

development , nervous system

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to GP130
	influenced by BHLHB9 in the brain
	interacting with the RAN-binding-protein-5 (RanBP5), BHLHB9 and protein phosphatase 2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CISS2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function in cold-induced sweating syndrome

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS