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FLASH GENE
Symbol CLCF1 contributors: mct - updated : 10-04-2007
HGNC name cardiotrophin-like cytokine factor 1
HGNC id 17412
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Lymphoid/Immunelymph node   predominantly
 spleen   predominantly
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a conserved binding site on ciliary neurotrophic factor receptor (CNTFR)
secondary structure alpha helices
conjugated GlycoP
HOMOLOGY
interspecies ortholog to murine Bsf3
ortholog to murine Clcf1
ortholog to rattus Clc
intraspecies paralog to CNTF
Homologene
FAMILY interleukin-6 cytokine family member
CATEGORY signaling cytokine
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • cytokine with B cell stimulating activity
  • activating IL6ST receptor, LIFR and signal transducer and activator of transcription 3 (STAT3)
  • second ligand for CNTFR
  • share a conserved binding site on ciliary neurotrophic factor receptor (CNTFR)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    cell communication
    PHYSIOLOGICAL PROCESS development , nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to GP130
  • influenced by BHLHB9 in the brain
  • interacting with the RAN-binding-protein-5 (RanBP5), BHLHB9 and protein phosphatase 2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CISS2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    in cold-induced sweating syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS